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The Wnt-signalling pathway is one of the core de-regulated pathways in chronic lymphocytic leukemia (CLL), activated in a subset of patients by somatic coding mutations. Here we describe an alternative mechanism of Wnt-activation in malignant B cells, mediated by Notch2 activity in mesenchymal strom...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-19 | PXD010401 | Pride
Environment-mediated drug resistance (EMDR) limits the efficacy of cancer therapies by providing anti-apoptotic signals from a non-malignant microenvironment to tumour cells. We show that EMDR is regulated by protein kinase C in stromal cells is required for EMDR. We used plasma membrane profiling t...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD011062 | Pride
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongsid...
Lymphoma samples using HumanOmni
Lymphoma samples using CytoSNP
Paired-end RNA sequencing using total RNA from 136 primary lymphoma samples. Sequencing was performed on the Illumina HiSeq2000 with 300bp insert size. The dataset contains FASTQ files.
Whole exome sequencing from matched tumor-control samples of 121 primary lymphoma samples. Sequencing was performed on Illumina HiSeq2000. The dataset contains FASTQ files.
Lymphoma samples using 450k
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