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ProteomicsLung proteome of the AAV-DTR/DT mouse model of acute epithelial lung injury
Injury of the lung epithelium is one of the initial events driving acute lung diseases such as acute lung injury and acute respiratory distress syndrome. Repeated epithelial injury followed by aberrant repair leads to fibroblast activation and extracellular matrix deposition and is therefore conside...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-04 | MSV000088510 | MassIVE
ProteomicsComparative proteomics of liver and plasma on the CDAA rat NASH model
Nonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing prevalence worldwide. Currently there are no approved drugs available. The development of new therapies is difficult as diagnosis and staging requires biopsies. Consequently, predictive plasma biomarkers would be ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-28 | PXD014751 | Pride
Lc-msms Plasma Han wistar rat Liver 
ProteomicsProteomic profiling of young and old mice in the bleomycin model
The most preclinical used in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2-3-month-old mice. Although this model resembles key aspects of idiopathic pulmonary fibrosis (IPF), there are limitations in its predictability for the human disease. One of the main diff...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD026222 | Pride
Bleomycin Idiopathic pulmonary fibrosis Tmt Fusion lumos Lc-ms Lung Sps ms3 C57bl/6j mouse 
ProteomicsBleomycin model of fibrosis and resolution phase in old and young mice
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of ...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-09 | PXD041050 | Pride
Bleomycin Dia Mouse Lung Fibrosis Age 
ProteomicsBleomycin model of fibrosis and resolution phase in old and young mice
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD040530 | Pride
Bleomycin Dia Mouse Lung Fibrosis Age 
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
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