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MetabolomicsDivergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucity of knowledge regarding the biology of T. congole...
2021-07-20 | MTBLS2372 | MetaboLights
UnknownCPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Not available
S-EPMC6127025 | biostudies-literature
UnknownBDNF promoter methylation and genetic variation in late-life depression.
Not available
S-EPMC4564567 | biostudies-literature
UnknownGenotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression.
Not available
S-EPMC6122720 | biostudies-literature
UnknownInvestigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression.
Not available
S-EPMC5657056 | biostudies-literature
UnknownField validation of a transcriptional assay for the prediction of age of uncaged Aedes aegypti mosquitoes in Northern Australia.
Not available
S-EPMC2826399 | biostudies-literature
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
ProteomicsProteomic and phosphoproteomic profiling of SFTPCI73T expressing patient-specific pluripotent stem cell-derived alveolar epithelial type 2 cells and their gene-edited corrected counterparts.
We performed proteomic and phosphoproteomic profiling of cells derived from human induced pluripotent stem cells (iPSCs) using our previously described distal lung directed differentiation protocol to generate alveolar epithelial type 2 cells (iAEC2s). We used the SPC2 human iPSC line and specifical...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD022334 | Pride
Autophagy Proteomics Pluripotent stem cells Pulmonary fibrosis Alveolar epithelial type 2 cells 
ProteomicsUbiquitome analysis of UHRF1 and UHRF2-deficient mESCs
The E3 ligase UHRF1 is an essential epigenetic cofactor for DNMT1 dependent maintenance DNA methylation, which provides a binding platform for DNMT1 by both cooperative binding of histones and hemi-methylated DNA as well as by ubiquitinating histone H3. Here, we conduct a comprehensive screen to ide...
ORGANISM(S): Mus musculus (Mouse) 
2017-10-24 | PXD006593 | Pride
Ubiquitination Paf Mouse embryonic stem cells Uhrf 
UnknownObjectively Assessed Weight Change and All-Cause Mortality among Community-Dwelling Older People.
Not available
S-EPMC9320907 | biostudies-literature
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