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ProteomicsDiscovery of lipotoxicity-sensitive transcription factors in non-alcoholic steatohepatitis
Non-alcoholic fatty liver disease is continuum of disorders among which non-alcoholic steatohepatitis (NASH) is particularly associated with a negative prognosis. Hepatocyte lipotoxicity is one of the main pathogenic factors of liver fibrosis and NASH. However, the molecular mechanisms regulating th...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-07-08 | PXD026717 | Pride
Tmt Transcription factor Non-alcoholic steatohepatitis 
ProteomicsTranscriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and Zeitgeber activity of endurance training in mouse skeletal muscle
Timed physical activity might potentiate the health benefits of training. The underlying signaling events triggered by exercise at different times of the day are, however, poorly understood. Here, we found that time-dependent variations in maximal treadmill exercise capacity of naïve mice were assoc...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-22 | PXD026461 | Pride
Exercise  skeletal muscle  transcriptomics  proteomics  metabolism  energy homeostasis  circadian clock  zeitgeber 
ProteomicsTORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
Target of rapamycin complex 1 (TORC1) promotes biogenesis and inhibits degradation of ribosomes in response to nutrient availability. To ensure a basal supply of ribosomes, cells preserve a small pool of dormant ribosomes under nutrient-limited conditions. The regulation of dormant ribosomes is poor...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-01-19 | PXD037117 | Pride
Protein synthesis Dormant ribosome Proteasome Torc1 Ribosome preservation factor Ribophagy 
ProteomicsPhotoaffinity capture compounds to profile the Magic Spot Nucleotide interactomes
Magic Spot Nucleotides (MSN) regulate the stringent response, a highly conserved bacterial stress adaptation mechanism, enabling survival when confronted with adverse external challenges. In times of antibiotic crisis, a detailed understanding of the stringent response is of critical importance, as ...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium Escherichia coli 
2026-07-27 | PXD032009 | Pride
Chemical proteomics Magic spot nucleotides (msn) Stringent response 
ProteomicsRNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates
The peroxisome-proliferator-activated receptor-γ coactivator-1α (PGC-1α) integrates environmental cues by controlling complex transcriptional networks in various metabolically active tissues. However, it is unclear how a transcriptional coregulator coordinates dynamic biological programs in response...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-19 | PXD026725 | Pride
Apms Muscle cells Lcms/ms 
UnknownCombinatorial biosynthesis of novel antibiotics related to daptomycin.
Not available
S-EPMC1859951 | biostudies-literature
UnknownAssessing the practice of total neoadjuvant therapy for rectal cancer: an online survey among radiation oncology departments in Germany and German-speaking regions of Austria and Switzerland.
Not available
S-EPMC11490463 | biostudies-literature
UnknownDiagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health.
Not available
S-EPMC5800006 | biostudies-literature
UnknownExogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.
Not available
S-EPMC4995078 | biostudies-literature
UnknownThe Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.
Not available
S-EPMC8821377 | biostudies-literature
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