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UnknownCoffee intake is associated with lower rates of liver disease progression in chronic hepatitis C.

Unlabelled

Higher coffee consumption has been associated inversely with the incidence of chronic liver disease in population studies. We examined the relationship of coffee consumption with liver disease progression in individuals with advanced hepatitis C-related liver disease. Baseline cof...
S-EPMC2783828 | biostudies-literature
UnknownVariants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.

Unlabelled

Combination treatment with pegylated-interferon-alpha (PEG IFN-alpha) and ribavirin, the current recommended therapy for chronic hepatitis C virus (HCV) infection, results in a sustained virological response (SVR) in only about half of patients. Because genes involved in the inter...
S-EPMC2692559 | biostudies-literature
UnknownAn IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C.

Background

Genetic variation in IL28B and other factors are associated with sustained virological response (SVR) after pegylated-interferon/ribavirin treatment for chronic hepatitis C (CHC). Using data from the HALT-C Trial, we developed a model to predict a patient's probability of SVR base...
S-EPMC3132753 | biostudies-literature
UnknownIron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C.

Background & aims

Iron may influence severity and progression of non-hemochromatotic liver diseases. Our aim was to assess the relationship of iron and HFE genetic variations to progression and outcomes in the HALT-C Trial and whether PegIFN therapy influenced iron variables.

Methods

...
S-EPMC3081953 | biostudies-literature
TranscriptomicsCopy number profiling of PE ovarian cancer lines
The PEO/PEA series of ovarian cancer cell lines was established in 1988 from progressive samples from three separate cases of ovarian cancer (Langdon et al., 1988). Copy number profiling of PE lines on Illumina Infinium Human1M-Duo v3 BeadChips
ORGANISM(S): Homo sapiens 
2010-06-28 | E-GEOD-18461 | biostudies-arrayexpress
TranscriptomicsValidation of a subset of copy number variants from GSE24424 by aCGH
This dataset was used to validate CNV predictions from GSE24424. We designed a custom CGH array to interrogate a total of 4,420 individual CNVs and their flanks predicted in 17 individuals. On the basis of a test that compares signals of probes located within to those mapping outside of CNVs (two-ta...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-24640 | biostudies-arrayexpress
TranscriptomicsExpression and CGH array profiling of ductal carcinoma (135 tumor samples)
A Cartes d'Identité des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 46 samples| Agilent SurePrint G3 Human CGH Microarray 4x180K Arrays : 135 samples| To explore the prognostic value of genomic alterations pr...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MTAB-748 | biostudies-arrayexpress
TranscriptomicsA Genome-wide Study of Cytogenetic Changes in Colorectal Cancer Using SNP Microarrays: Possibilities for Future Personalized Treatment
In colorectal cancer (CRC), chromosomal instability (CIN) is typically studied using comparative-genomic hybridization (CGH) arrays. We studied paired (tumor and surrounding healthy) fresh-frozen tissue from 86 CRC patients using Illumina’s Infinium-based SNP array. This method allowed us to study C...
ORGANISM(S): Homo sapiens 
2014-12-19 | E-GEOD-34678 | biostudies-arrayexpress
TranscriptomicsReplication timing of control and siRNA PR-set7 cells
Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the monomethylation, is a critical determinant of licensing ...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-69083 | biostudies-arrayexpress
TranscriptomicsReplication timing of control and suv4-20h (KO and inducible mutant) cells
Although histone modifications have been implicated in many DNA-dependent processes, their precise role in DNA replication remains poorly understood. Here, we show that the regulation of histone H4-K20 methylation states, in particular for the trimethylation, is a critical determinant of licensing a...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-69084 | biostudies-arrayexpress
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