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ProteomicsNovel asymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus
How essential asymmetries are built into icosahedral virus to facilitate directional genome egress is unknown. Here we capture the structure and dynamics of disassembly intermediates of an icosahedral virus. We reveal localized RNA density poised for release beneath 5-fold axes on one half of the vi...
ORGANISM(S): Turnip crinkle virus 
2025-11-06 | PXD067878 | Pride
Turnip crinkle virus Hdxms Rna egress Asymmetry Isopeptide bond 
TranscriptomicsSingle-cell RNA sequencing of a 3D blood-brain-barrier model perfused with P. falciparum-infected red blood cells and egress products
This dataset consists of two individual sample-multiplexing (MULTI-seq) single-cell RNA sequencing experiments, MB10x01 and MB10x02. Single-cell RNA sequencing (10X Genomics) analyses were performed on a microfluidic 3D in vitro blood-brain-barrier model (containing primary human brain microvascular...
ORGANISM(S): Homo sapiens 
2025-06-25 | E-MTAB-14463 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of HBMEC, iBMEC-like cells, and ETS-iBMEC in Response to Plasmodium falciparum Egress Products
This dataset comprises bulk RNA sequencing (RNA-seq) data generated from primary human brain microvascular endothelial cells (HBMECs), induced pluripotent stem cell (iPSC)-derived iBMEC-like cells, and ETS-transcription factor-guided iPSC-derived endothelial cells (ETS-iBMEC). Cells were cultured as...
ORGANISM(S): Homo sapiens 
2026-03-05 | E-MTAB-14937 | biostudies-arrayexpress
ProteomicsRNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Nuclear Egress
DDX3X is a mammalian RNA helicase that regulates RNA metabolism, cancers, innate immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear DNA replicating virus, highjacks redirects DDX3X to the nuclear envelope where it surprisingly modulates the exit of newly assembled...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD039403 | Pride
Herpesvirus Nec Hsv Helicase Herpes Ddx Ddx3 Host-pathogen interaction Us3 Ul31 
GenomicsRNA-seq of IMR90 senescence with CCF nuclear egress inhibition
RNA-seq of IMR90 senescence with CCF nuclear egress inhibition
PRJNA1136149 | ENA
TranscriptomicsEgress of mature murine regulatory T cells from the thymus requires RelA
The mechanism of egress of mature regulatory T cells (Tregs) from the thymus to the periphery remains enigmatic, as does the nature of those factors expressed in the thymic environment. Here, we examined the fate of thymic Tregs in TNFα/RelA double-knockout (TA-KO) mice, because TA-KO mice retain a...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64191 | biostudies-arrayexpress
GenomicsHSV-1 exploits host heterochromatin for egress [RNA-seq]
HSV-1 exploits host heterochromatin for egress [RNA-seq]
PRJNA861940 | ENA
UnknownAsymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus.
Not available
S-EPMC12700214 | biostudies-literature
ProteomicsMyosin-9 is required for lysosome-mediated nonlytic reovirus egress
Mammalian orthoreoviruses (reoviruses) are nonenveloped, double-stranded RNA viruses that assemble progeny particles in cytoplasmic viral factories (VFs) and exit some types of cells using a nonlytic release mechanism. In human brain microvascular endothelial cells (HBMECs), progeny reovirus virions...
ORGANISM(S): Homo sapiens (Human) Orthoreovirus 
2025-10-10 | PXD068971 | Pride
Reovirus  virus egress  myosin-9  proteomics  imaging 
GenomicsBulk RNA-seq of HBMEC, iBMEC-like cells, and ETS-iBMEC in Response to Plasmodium falciparum Egress Products
Bulk RNA-seq of HBMEC, iBMEC-like cells, and ETS-iBMEC in Response to Plasmodium falciparum Egress Products
PRJEB86852 | ENA
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