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MetabolomicsA multi-omics dataset of heat-shock response in the yeast RNA binding protein Mip6 (NMR assay)

Gene expression is a biological process regulated at different molecular levels, including chromatin accessibility, transcription, and RNA maturation and transport. In addition, these regulatory mechanisms have strong links with cellular metabolism. Here we present a multi-omics dataset that capt...

2020-02-14 | MTBLS1320 | MetaboLights
GenomicsNuclear export of circular RNA
Nuclear export of circular RNA
PRJNA988001 | ENA
GenomicsNuclear export of circular RNA
Nuclear export of circular RNA
PRJNA941274 | ENA
ProteomicsProteins that interact with PHAX and UAP56 from HeLa nuclear extracts
HeLa nuclear extracts and RNase A were incubated with GST-PHAX and FLAG-UAP56 in the presence of ATP. The mixture was subjected to immunoprecipitation. The bound proteins were eluted with FLAG peptide. The eluate was subjected to GST pull-down. The bound proteins were treated with HRV 3C protease. S...
ORGANISM(S): Homo Sapiens (human) 
2025-06-28 | PXD053480 | JPOST Repository
ProteomicsNEAT1 Regulates BMSCs Aging Through Disruption of FGF2 Nuclear Transport
Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to eluc...
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059860 |
ProteomicsSpecialization of the Drosophila nuclear export family protein, Nxf3, for piRNA precursor export
The piRNA pathway is a conserved small RNA-based immune system that protects animal germ cell genomes from the harmful effects of transposon mobilisation. In Drosophila ovaries, most piRNAs originate from dual-strand clusters, which generate piRNAs from both genomic strands. Dual-strand clusters use...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-07-29 | PXD014472 | Pride
Pirna rna export piwi drosophila transposons 
TranscriptomicsKnockdown of SR protein family in P19 cells and RNA-seq of cytoplasmic and whole cell polyA+ RNA
Our data suggest that all SR proteins contribute to mRNA export via NXF1. To identify endogenous export targets we depleted all seven SR proteins individually from P19 WT cells prepared cytoplasmic fractions. We sequenced the cytoplasmic fraction and as a control whole celll RNA from the identical s...
ORGANISM(S): Mus musculus 
2016-03-07 | E-GEOD-69733 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of dU2AF50 in Drosophila mel2 cells and profiling of nuclear and cytoplasmic fractions
Nuclear and cytoplasmic RNA were extracted by hypotonic cell lysis from D.-mel2 cell knock down by RNAi against dU2AF50 or with non-specific dsRNA.
ORGANISM(S): Drosophila melanogaster 
2007-07-05 | E-GEOD-1344 | biostudies-arrayexpress
GenomicsAltered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
PRJNA1073893 | ENA
TranscriptomicsSelective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
The nuclear phase of the gene expression pathway culminates in the export of mature mRNAs to the cytoplasm through nuclear pore complexes (NPCs). GANP (Germinal-centre Associated Nuclear Protein) promotes the transfer to NPCs of mRNAs bound to the transport factor NXF1. Here, we demonstrate that GAN...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-54481 | biostudies-arrayexpress
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