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TranscriptomicsRNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryo
Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient. Most SCNT-generated embryos die after implantation because of unidentified, complex epigenetic errors in the process of postimplantation embryonic development. Here, we identified the most upstream level of dysfunction le...
ORGANISM(S): Mus musculus 
2011-11-17 | E-GEOD-33208 | biostudies-arrayexpress
TranscriptomicsRNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This study aimed to identify genes and molecular processes downstream of MLL-AF9 (alias MLL-MLLT3) which could assist to develop new targeted therapi...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-36592 | biostudies-arrayexpress
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry -SAM50
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD004979 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry – PEX14c
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD004972 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry - ATOM40p
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD004917 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry – ATOM40c
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD004950 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
GenomicsMetabolic and transcriptome responses of RNAi-mediated AMPKα knockdown in Tribolium castaneum
Metabolic and transcriptome responses of RNAi-mediated AMPKα knockdown in Tribolium castaneum
PRJNA650526 | ENA
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry - ATOM40 whole cells
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD005725 | Pride
Trypanosoma brucei Proteomics Glycosomes Organellar protein import Mitochondria Silac Importomics Rnai-mediated protein knockdown 
TranscriptomicsRNAi knock down of Sox4 in a human adenoid cystic carcinoma cell line reveals that knockdown of Sox4 expression induces apoptosis
Sox4 is upregulated in adenoid cystic carcinoma (ACC). The ACC3 cell line is the most widely available cell culture model system of this tumor type. RNAi mediated knockdown of Sox4 in ACC3 cells induces apoptosis.
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-4225 | biostudies-arrayexpress
ProteomicsCharting Organellar Importomes by Quantitative Mass Spectrometry - ERV1 organelle-enriched fractions
Protein import into organelles is essential for all eukaryotes and facilitated by multi-protein translocation machineries. Analyzing whether a protein is transported into an organelle is largely restricted to single constituents. This renders knowledge about imported proteins incomplete, limiting ou...
ORGANISM(S): Trypanosoma brucei 
2017-06-14 | PXD005730 | Pride
Trypanosoma brucei Proteomics Organellar protein import Mitochondria Stable dimethyl labeling Importomics Rnai-mediated protein knockdown 
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