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ProteomicsIdentification of the RNF12/RLIM proximal proteome
RNF12/RLIM is an E3 ubiquitin ligase that plays key developmental roles and is genetically disrupted in the neurodevelopmental disorder Tonne-Kalscheuer syndrome. RNF12/RLIM regulates X-chromosome inactivation and controls the expression of neural and gametogenesis related genes. To better understan...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-09 | PXD046733 | Pride
E3 ubiquitin ligase  rnf12/rlim  embryonic stem cells  protein ubiquitylation  turboid chromatin  transcription 
ProteomicsREX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice.
In mice, imprinted X-chromosome inactivation (iXCI) of the paternal X in the pre-implantation embryo and extra-embryonic tissues is followed by X-reactivation in the epiblast precursors of the inner cell mass (ICM) of the blastocyst, to facilitate initiation of random XCI (rXCI) in all embryonic tis...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-15 | PXD010944 | Pride
Xci Proteomics Silac Rnf12 Mouse Rex1 
ProteomicsQuantitative Proteomic Identification of Proteins that are Responsive to RNF12 E3 Ligase Ubiquitin Activity
Rlim-/y mouse embryonic stem cells (mESCs) were transfected with either empty pCAGGS vector, HA-RNF12 or HA-RNF12 (H569A/C572A). Experiment was performed in biological triplicate (9 samples in total).
ORGANISM(S): Mus musculus (Mouse) 
2022-06-30 | PXD032317 | Pride
Mescs Rnf12 Tmt Lc-ms Quantification E3 ligase Ubiquitin 
GenomicsRNF12 E3 ligase activity-dependent transcriptional profile in mouse embryonic stem cells
RNF12 E3 ligase activity-dependent transcriptional profile in mouse embryonic stem cells
PRJNA629110 | ENA
GenomicsChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
PRJNA990693 | ENA
ProteomicsChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls gene-specific transcription
Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which is mutated in an X-linked intellectual disability disorder and controls developmental gene expression by ubiquitylating the REX1 transcription factor. H...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-01-09 | PXD047197 | Pride
Rnf12/rlim Transcription E3 ubiquitin ligase Chromatin 
GenomicsChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene expression by ubiquitylating the REX1 transcription factor and is mutated in an X-linked intellectual disability disorder. H...
ORGANISM(S): Mus musculus 
2024-01-08 | GSE236354 | GEO
TranscriptomicsRNF12 E3 ligase activity-dependent transcriptional profile in mouse embryonic stem cells
RNF12 is a developmental E3 ligase mutated in Tonne-Kalscheuer Syndrome patients. To identify the gene expression programme controlled by RNF12 activity in mouse embryonic stem cells we employ RNA-Sequencing.
ORGANISM(S): Mus musculus 
2020-04-29 | GSE149554 | GEO
UnknownChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses.
Not available
S-EPMC10781586 | biostudies-literature
UnknownREX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice.
Not available
S-EPMC6232137 | biostudies-literature
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