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ProteomicsIdentification of the RNF12/RLIM proximal proteome
RNF12/RLIM is an E3 ubiquitin ligase that plays key developmental roles and is genetically disrupted in the neurodevelopmental disorder Tonne-Kalscheuer syndrome. RNF12/RLIM regulates X-chromosome inactivation and controls the expression of neural and gametogenesis related genes. To better understan...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-09 | PXD046733 | Pride
E3 ubiquitin ligase  rnf12/rlim  embryonic stem cells  protein ubiquitylation  turboid chromatin  transcription 
GenomicsChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
PRJNA990693 | ENA
UnknownRlim/Rnf12, Rex1, and X Chromosome Inactivation.
Not available
S-EPMC6834644 | biostudies-literature
ProteomicsChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls gene-specific transcription
Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which is mutated in an X-linked intellectual disability disorder and controls developmental gene expression by ubiquitylating the REX1 transcription factor. H...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-01-09 | PXD047197 | Pride
Rnf12/rlim Transcription E3 ubiquitin ligase Chromatin 
UnknownChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses.
Not available
S-EPMC10781586 | biostudies-literature
GenomicsChromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene expression by ubiquitylating the REX1 transcription factor and is mutated in an X-linked intellectual disability disorder. H...
ORGANISM(S): Mus musculus 
2024-01-08 | GSE236354 | GEO
UnknownA novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne-Kalscheuer syndrome.
Not available
S-EPMC8100121 | biostudies-literature
ProteomicsQuantitative Proteomic Identification of Proteins that are Responsive to RNF12 E3 Ligase Ubiquitin Activity
Rlim-/y mouse embryonic stem cells (mESCs) were transfected with either empty pCAGGS vector, HA-RNF12 or HA-RNF12 (H569A/C572A). Experiment was performed in biological triplicate (9 samples in total).
ORGANISM(S): Mus musculus (Mouse) 
2022-06-30 | PXD032317 | Pride
Mescs Rnf12 Tmt Lc-ms Quantification E3 ligase Ubiquitin 
TranscriptomicsExpression analysis of blastocysts in Kdm4b-PEs
To identify the genes that are controled by H3K9me3 modification in PEs, we conducted transcriptome analysis using Egfp-, Kdm4b-PEs, and IVF embryos at blastocyst stages. Kdm4b or Egfp mRNA injected oocytes were parthenogenetically activated. IVF embryos were generated according to standard protcol...
ORGANISM(S): Mus musculus 
2014-11-15 | E-GEOD-53662 | biostudies-arrayexpress
UnknownAn RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
Not available
S-EPMC7613676 | biostudies-literature
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