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TranscriptomicsRNA-Seq of control and RNPS1 knockdown with or without RNPS1 wildtype or RNPS1-RRM domain rescue in Flp-In T-REx 293 cells
RNPS1 is a splicing regulatory protein and a component of the ASAP/PSAP complex, which is associated with the exon junction complex and modulates alternative splicing. It was previously postulated that the isolated RRM domain of RNPS1 in complex with ASAP/PSAP is able to regulate certain alternative...
ORGANISM(S): Homo sapiens 
2022-05-06 | E-MTAB-10770 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of control and RNPS1 knockdown with or without RNPS1-RRM domain rescue in HeLa Tet-Off cells
RNPS1 is a splicing regulatory protein and a component of the ASAP/PSAP complex, which is associated with the exon junction complex and modulates alternative splicing. It was previously postulated that the isolated RRM domain of RNPS1 in complex with ASAP/PSAP is able to regulate certain alternative...
ORGANISM(S): Homo sapiens 
2022-06-22 | E-MTAB-10768 | biostudies-arrayexpress
ProteomicsProximity labelling of FLAG-TurboID- or Myc-UltraID-tagged full-length RNPS1 or RNPS1 deletion mutants followed by proteomics analysis
RNPS1 is a component of the EJC-associated ASAP and PSAP complex. We used full-length RNPS1, RNPS1 with a C-terminal deletion and the RNPS1 RRM in a proximity labeling approach. We aimed to confirm interaction partners of RNPS1 previously identified by MS of RNPS1 IPs using the same RNPS1 deletion m...
ORGANISM(S): Homo sapiens (Human) 
2022-05-16 | PXD032952 | Pride
Rnps1 Exon junction complex Alternative splicing 
TranscriptomicsRNA-Seq of control, RNPS1 knockdown and rescue in HeLa cells
We report the knockdown and rescue of RNPS1, a component of the ASAP and PSAP complexes and, hence, an auxiliary component of the exon junction complex. The studied conditions show an extensive change in alternative splicing and the cell's transcriptome. For the knockdown, HeLa cells were transfect...
ORGANISM(S): Homo sapiens 
2018-11-01 | E-MTAB-6564 | biostudies-arrayexpress
ProteomicsInsights into transcriptome surveillance and alternative splicing regulation by the EJC-associated splicing factor RNPS1
Alternative splicing of pre-mRNAs increases the potential for regulation and complexity of gene expression. The exon junction complex (EJC) and its associated splicing factor RNPS1 were recently shown to suppress mis-splicing resulting from the usage of cryptic and reconstituted 5’ and 3’ splice sit...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD027251 | Pride
Exon junction complex Rnps1 Mrna splicing 
GenomicsRNA-Seq of control and RNPS1 knockdown with or without RNPS1 wildtype or RNPS1-RRM domain rescue in Flp-In T-REx 293 cells
RNA-Seq of control and RNPS1 knockdown with or without RNPS1 wildtype or RNPS1-RRM domain rescue in Flp-In T-REx 293 cells
PRJEB46521 | ENA
GenomicsRNA-Seq of control and RNPS1 knockdown with or without RNPS1-RRM domain rescue in HeLa Tet-Off cells
RNA-Seq of control and RNPS1 knockdown with or without RNPS1-RRM domain rescue in HeLa Tet-Off cells
PRJEB46514 | ENA
TranscriptomicsThe exon junction complex controls transposable element activity by ensuring the faithful splicing of the piwi transcript
The exon junction complex (EJC) is a highly conserved ribonucleoprotein complex which binds RNAs at a late stage of the splicing reaction and remains associated following export to the cytoplasm. This complex is involved in several cellular post-transcriptional processes including mRNA localization,...
ORGANISM(S): Drosophila melanogaster 
2014-09-08 | E-GEOD-57710 | biostudies-arrayexpress
GenomicsRNPS1 inhibits excessive TNF/TNFR signaling to support hematopoiesis in mice
RNPS1 inhibits excessive TNF/TNFR signaling to support hematopoiesis in mice
PRJNA649939 | ENA
TranscriptomicsThe exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript
The exon junction complex (EJC) is a highly conserved ribonucleoprotein complex which binds RNAs during splicing and remains associated with them following export to the cytoplasm. While the role of this complex in mRNA localization, translation and degradation has been well characterized, its mecha...
ORGANISM(S): Drosophila melanogaster 
2014-08-14 | E-GEOD-59327 | biostudies-arrayexpress
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