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ProteomicsZAP-70 promotes microenvironment interactions and increases protein-translation in chronic lymphocytic leukemia
The expression of ZAP-70 in a subset of CLL patients strongly correlates with a more aggressive clinical course, though the exact underlying mechanisms remain elusive. The ability of ZAP-70 to enhance B cell receptor (BCR) signaling, independently of its kinase function, likely contributes. Here we ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD019465 | Pride
Zap70 Q-plex_rime Leukemia 
ProteomicsDefining Essential Regulators of Naïve Human Pluripotent Cell Reprogramming
Defining how human pluripotent cell identity is controlled and in particular how naïve pluripotency is acquired during cell reprogramming is crucial for the future applications of pluripotent stem cells. However, the regulatory pathways of naïve cell reprogramming remain incompletely understood. Her...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD023547 | Pride
Pluripotent stem cells  embryonic stem cells  pluripotency  reprogramming  cell state  crispr  polycomb  prc1  histone deacetylases  hdacs. 
ProteomicsRetroviral transduction of NOTCH1 into primary human Chronic Lymphocytic Leukemia cells unravels immune escape-mechanisms
Functional studies to investigate gene mutations recurrent in B cell lymphoma have been hampered by the inability to genetically manipulate primary cells, attributed to low transduction efficacy and procedure-associated toxicity. Alternative approaches utilize cell lines and mouse models, which ofte...
ORGANISM(S): Homo sapiens (Human) 
2022-08-26 | PXD024112 | Pride
Notch1 Mutated gene Chronic lymphocytic leukemia (cll) Co-activator ciita Mantle cell lymphoma (mcl) Hla-class ii locus 
ProteomicsAZD4573 is a highly selective CDK9 inhibitor that suppresses Mcl-1 and induces apoptosis in hematological cancer cells
Phosphorylation of RNA polymerase II by cyclin-dependent kinase 9 (CDK9) is crucial for transcriptional regulation, and acute inhibition of CDK9 results in the rapid downregulation of genes with short-lived transcripts and labile proteins. Multiple non-selective CDK9 inhibitors have progressed clini...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013796 | Pride
A selective cdk9 inhibitor Azd4573 Targets mcl-1 
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