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TranscriptomicsCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells and enables these cells to spontaneously...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-43133 | biostudies-arrayexpress
TranscriptomicsRescue of KRAS suppression in HCT116 colon cancer cell line
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically ex...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-55942 | biostudies-arrayexpress
TranscriptomicsKRAS and YAP1 converge to regulate EMT and tumor survival
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically ex...
ORGANISM(S): Mus musculus 
2014-07-27 | E-GEOD-56175 | biostudies-arrayexpress
ProteomicsCD47 interactions with exportin-1 regulate targeting of m7G-capped RNAs to extracellular vesicles
CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a membrane component of extracellular vesicles (EVs) released by various cell types. Previous studies identified CD47-dependent functional effects of EVs on target cells, mediated by delivery of their RNA contents, a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-01 | MSV000086969 | MassIVE
UnknownMirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.
Not available
S-EPMC3637175 | biostudies-literature
UnknownA Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.
Not available
S-EPMC5294886 | biostudies-literature
UnknownCommunity-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths.
Not available
S-EPMC11761538 | biostudies-literature
UnknownHemorrhagic transformation in acute ischemic stroke: hemorrhagic subtypes and symptomatic intracranial hemorrhage.
Not available
S-EPMC12322388 | biostudies-literature
UnknownObservation of quantum entanglement with top quarks at the ATLAS detector.
Not available
S-EPMC11410654 | biostudies-literature
UnknownBiallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections.
Not available
S-EPMC10932913 | biostudies-literature
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