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Oxidative stress (OS) results from genetic defects or stressful environmental challenges that cause unchecked production of reactive oxygen species (ROS). OS has been implicated in many diseases due to its wide ranging damage to nucleic acids, proteins and lipids. Using Halobacterium salinarum NRC...
ORGANISM(S): Halobacterium salinarum 
Methionine adenosyltransferase 1a (Mat1a) is responsible for hepatic biosynthesis of S-adenosyl-L-methionine (SAMe), the principal cellular methyl donor. Mat1a -/- mice have decreased hepatic SAMe levels, and spontaneously develop nonalcoholic steatohepatitis (NASH) which can be reversed with exogen...
ORGANISM(S): Homo Sapiens Mus Musculus 
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
Aedes aegypti mosquitoes vector several arboviruses of global health significance, including dengue viruses and chikungunya virus. RNA interference (RNAi) plays an important role in antiviral immunity, gene regulation and protection from transposable elements. Double-stranded RNA binding proteins (d...
ORGANISM(S): Aedes aegypti 
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute ...
ORGANISM(S): Mus musculus 
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