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ProteomicsMetabolism as an early predictor of DPSCs aging
Tissue resident adult stem cells are known to participate in tissue regeneration and repair that follows cell turnover, or injury. It has been well established that aging impedes the regeneration capabilities at the cellular level, but it is not clear if the different onset of stem cell aging betwee...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011962 | Pride
Aging stem cell 
ProteomicsAmino acid priming of mTOR is essential for heart regeneration
For a short period of time in mammalian neonates, the mammalian heart can regenerate via cardiomyocyte proliferation. This regenerative capacity is largely absent in adults. In other organisms, including zebrafish, damaged hearts can regenerate throughout their lifespans. Many studies have been perf...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-15 | PXD011791 | Pride
Heart regeneration Mtor 
ProteomicsFolliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
Using co-immunoprecipitation and mass spectrometry analysis we identify unique FLCN binding partners. The interactions of FLCN with components of the mTOR pathway (mTORC1 and mTORC2) reveal a mechanism of FLCN function during exit from naïve pluripotency.
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD011736 | Pride
Folliculin Mtor 
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