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ProteomicsHsa-miR-139-5p expression regulates the abundance of proteins related to poor survival cancer in CAL-62 thyroid cancer cell line
We studied the impact of hsa-miR-139-5p on the protein output by means of an iTRAQ-based approach. First, we established two CAL-62 isogenic cell lines expressing either the mature hsa-miR-139-5p or a non-targeting control upon a doxycycline inducible promoter (PTRE3G-tGFP, Dharmacon). Total protein...
ORGANISM(S): Homo sapiens (Human) 
2019-08-13 | PXD011901 | Pride
Thyroid cancer Cal-62 Hsa-mir-139-5p Impact Itraq 
TranscriptomicsOpposing Effects of HIF1M-NM-1 and HIF2M-NM-1 on Chromaffin Cell Phenotypic Features and Tumor Cell Proliferation: Insights from MAX
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-51087 | biostudies-arrayexpress
TranscriptomicsMIRnome Profiling of Hereditary Pheochromocytoma and Paraganglioma Reveals Specific Signatures According to Primary Mutation: Possible Implications in the Differentiation Status of Tumor Cells
Pheochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine neoplasias of neural crest origin. They can be part of several syndromes, and their mRNA profile is dependent on genetic background, but questions related to clinical behavior or even main location remain unanswered. MicroRNAs ar...
ORGANISM(S): Homo sapiens 
2013-07-02 | E-GEOD-29742 | biostudies-arrayexpress
TranscriptomicsOpposing Effects of HIF1M-NM-1 and HIF2M-NM-1 on Chromaffin Cell Phenotypic Features and Tumor Cell Proliferation: Insights from MAX [human]
Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To establish whether PPGL phenotypic differences reflect a MAX-mediated mechanism and opposing influences ...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-51081 | biostudies-arrayexpress
TranscriptomicsDNA methylation profile in well-differentiated cancer uncoves another source of diagnostic and prognostic markers
By characterizing at the genome-wide level the DNA methylation patterns of the largest series of well-differentiated thyroid tumors described to date, we provide novel insights into the biology underlying on the one hand the histological heterogeneity, and on the other differential patient outcomes ...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-51090 | biostudies-arrayexpress
TranscriptomicsOpposing Effects of HIF1α and HIF2α on Chromaffin Cell Phenotypic Features and Tumor Cell Proliferation: Insights from MAX [rat]
Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To establish whether PPGL phenotypic differences reflect a MAX-mediated mechanism and opposing influences ...
ORGANISM(S): Rattus norvegicus 
2014-09-18 | E-GEOD-50941 | biostudies-arrayexpress
TranscriptomicsDIFFERENTIAL GENE EXPRESSION OF MEDULLARY THYROID CARCINOMA REVEALS SPECIFIC MARKERS ASSOCIATED WITH GENETIC CONDITIONS.
Transcriptional analysis of 49 primary medullary thyroid carcinoma tumors. Comparisons MTCM918T vs MTC634 and MTCM918T vs MTCWT. 49 (52 hybridized tumors with 3 replicates) primary Medullary Thyroid Carcinoma (MTC) cases were hybridized onto a cDNA microarray in order to identify the unique markers ...
ORGANISM(S): Homo sapiens 
2013-11-26 | E-GEOD-32662 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling in pheochromocytoma and paraganglioma reveals diagnostic and prognostic markers
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net):we explored DNA methylation patterns associated with PPGL malignancy using two large and well characterized cohorts of PPGL collected through a multi-institutional collaborati...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-62082 | biostudies-arrayexpress
TranscriptomicsmicroRNAseq of clear-cell renal cell carcinoma on surgical resection specimens of untreated primary tumors in humans
We aimed to assess differences in miRNA expression profiles in transcriptomic molecular subtypes of ccRCC (Beuselinck et al, Clinical Cancer Research 2015) and to correlate miRNAs with overal survival since diagnosis of ccRCC. Sequencing was done for 129 primary ccRCC (formalin-fixed paraffin-embe...
ORGANISM(S): Homo sapiens 
2020-07-22 | E-MTAB-9380 | biostudies-arrayexpress
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