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UnknownImpact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: a pooled analysis of individual patient data from four randomized, controlled trials.
Not available
S-EPMC4374386 | biostudies-literature
ProteomicsOn the relationship of protein and mRNA dynamics in vertebrate embryonic development
How the fertilized egg develops the anatomy of an adult ultimately must be explained at the biochemical level. Deeply connected to the anatomy is the complement of proteins and RNAs expressed during embryogenesis. The relationship of mRNA and respective protein expression dynamics during development...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2015-10-20 | PXD002349 | Pride
Protein dynamics Mrna dynamics Xenopus Embryonic development 
UnknownInitial experience with CDK4/6 inhibitor-based therapies compared to antihormone monotherapies in routine clinical use in patients with hormone receptor positive, HER2 negative breast cancer - Data from the PRAEGNANT research network for the first 2 years of drug availability in Germany.
Not available
S-EPMC7509062 | biostudies-literature
ProteomicsDeep Proteomics of the Xenopus laevis Egg using an mRNA-derived Reference Database
Mass spectrometry based proteomics enables the global identification and quantification of proteins and their post-translational modifications in complex biological samples. Proteomic analysis requires a complete and accurate reference set of proteins, and is therefore largely restricted to model or...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2014-05-30 | PXD000926 | Pride
Genome-free Egg Development Xenopus laevis Metaphase Meiosis 
GenomicsNucleoporin Nup153 Regulates Stem Cell Pluripotency through Gene Silencing
Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), the transport channels that mediate nuclear transport. Recent evidence suggest that several Nups have additional roles in controlling the activation and silencing of developme...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-64008 | biostudies-arrayexpress
ProteomicsThe Nuclear Proteome of a Vertebrate
Despite the nucleus’ central role in multi-cellular biology, it is still poorly understood how the cell’s proteome is partitioned between the nucleus and cytoplasm. This is mostly due to the difficulty of separating the nuclear and cytoplasmic contents and the challenge to comprehensively measure re...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2015-09-17 | PXD001297 | Pride
Nucleus Tmtc Xenopus Multinotchms3 
TranscriptomicsBaker_Stem_Cells
Gene expression studies of human embryonic stem cells undergoing directed differentiation to endothelial cells to identify key transcriptional changes during differentiation
ORGANISM(S): Homo sapiens 
2013-03-19 | E-MTAB-1510 | biostudies-arrayexpress
TranscriptomicsTracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: a Link Between Stalled Polyribosomes and RNA Granules
Local translation at the synapse plays key roles in neuron development and activity-dependent synaptic plasticity. mRNAs are translocated from the neuronal soma to the distant synapses as compacted ribonucleoparticles referred to as RNA granules. These contain many RNA-binding proteins, including th...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-83835 | biostudies-arrayexpress
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Cell Model]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78959 | biostudies-arrayexpress
TranscriptomicsModeling the Neuropathology of Tuberous Sclerosis with Human Stem Cells Reveals a Role for Inflammation and Angiogenic Growth Factors [Treatment]
Tuberous sclerosis complex (TSC) is a rare genetic disease characterized by mTOR hyperfunction induced benign tumor growths in multiple organs and neurological symptoms. Because the molecular pathology is highly complex and the etiology poorly understood we employed a defined human neuronal model wi...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-78960 | biostudies-arrayexpress
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