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ProteomicsSynaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein pathology
Lewy body inclusions enriched with aggregated forms of the presynaptic protein alpha-synuclein (aSyn) are a hallmark of synucleinopathy diseases such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). To model this pathology, C57 mice were injected in the cortex or striatum with prefor...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-25 | PXD058091 | Pride
Mus musculus Phosphoproteome Cortex Parkinson's disease Preformed fibrils Dementia with lewy bodies Alpha-synuclein 
ProteomicsIdentification of novel kinases of Tau using fluorescence complementation mass spectrometry (FCMS)
Hyperphosphorylation of the microtubule-associated protein Tau is a major hallmark of Alzheimer’s disease (AD) and other tauopathies. Understanding the protein kinases that phosphorylate Tau is critical for the development of new drugs that target Tau phosphorylation. At present, the repertoire of t...
ORGANISM(S): Homo Sapiens (human) 
2022-11-10 | PXD036956 | JPOST Repository
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