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TranscriptomicsGenomic aberrations in distant fields from oral potentially malignant lesions by high resolution DNA flow cytometry and array-CGH
The aim of the study was to address the concept of field cancerization in oral cancer. The presence of genomic aberrations, indicative of chromosomal instability (CIN), in oral distant fields (ODFs) of visually normal and non-dysplastic mucosa at the mirror image from concomitant oral potentially ma...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28906 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of Escherichia coli O157 TUV93-0 to small molecule inhibitors of TTS
The transcriptional profile of Escherichia coli O157 treated with small molecule inhibitors of type III secretion was determined. Four variations of the small molecule inhibitor were assessed for global changes in transcription by treating cells with 20uM of inhibitor or an equivalent volume of DMSO...
ORGANISM(S): Escherichia coli 
2009-08-10 | E-GEOD-10319 | biostudies-arrayexpress
TranscriptomicsRNA-Seq profiling of S. Cerevisiae WT BY4741 cells and MOH1-knockout mutants of BY4741 cells (moh1∆) after growth on YPD-Agar for 40 hours
The Yippee-like (YPEL) proteins are a conserved eukaryotic gene family implicated in proliferation, senescence, and stress adaptation. In humans, five paralogs (YPEL1–YPEL5) are widely expressed and encode proteins with high sequence similarity, but the molecular basis of their functions remains poo...
ORGANISM(S): Saccharomyces cerevisiae S288c 
2026-06-15 | E-MTAB-16090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae to high carbon dioxide concentrations
Physiological effects of carbon dioxide and impact on genome-wide transcript profiles were analysed in chemostat cultures of Saccharomyces cerevisiae. In anaerobic, glucose-limited chemostat cultures grown at atmospheric pressure, cultivation under CO2-saturated conditions had only a marginal (<10%)...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-8900 | biostudies-arrayexpress
GenomicsTreatment of prostate cancer cells with S-adenosylmethionine leads to genomewide alterations of transcription profiles.
The analysis investigates the impact of methyl donor S-adenosylmethionin on transcription and methylation profiles of prostate carcinoma cells. PC-3 cells (Prostatecarcinoma cells) were treated with 160 micromolar S-adenosylmethionine or vehicle
ORGANISM(S): Homo sapiens 
2015-07-25 | E-GEOD-71303 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Daphnia magna treated with: cadmium, pH, lufenuron, calcium limitation and ibuprofen for 24 performed in replicate to assess their effect on stress reponse and growth
Microarray Construction The D. magna microarray was constructed using DNA fragments from three sources: i) Stress-specific cDNAs were generated using Selective Subtractive Hybridisation (SSH) on organisms exposed to the stressors shown in Table 1. SSH was performed with forward and reverse subtrac...
ORGANISM(S): Daphnia magna 
2007-11-05 | E-MAXD-20 | biostudies-arrayexpress
GenomicsCTCF demarcates chromatin domains
Insulators are DNA elements, which prevent inappropriate interactions between the neighboring regions of the genome. They can be functionally classified as either enhancer blockers or domain barriers. CTCF (CCCTC binding factor) is the only known major insulator binding protein in the vertebrates a...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-12889 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae wild type and leu3 mutant strains in ethanol-limited and ammonium-limited conditions
Transcriptional regulation of branched-chain amino acid metabolism in Saccharomyces cerevisiae involves two key regulator proteins, Leu3p and Gcn4p. Leu3p is a pathway-specific regulator, known to regulate six genes involved in branched-chain amino acid metabolism and one gene in nitrogen assimilati...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-2076 | biostudies-arrayexpress
UnknownTransferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing.
Not available
S-EPMC12451229 | biostudies-literature
TranscriptomicsThe S-adenosyl-homosteine hydrolase inhibitor DZNeP unspecifically affects histone methylation patterns in embryos and results in developmental aberrations
3-deazaneplanocin A (DZNeP) is a promising cancer drug affecting the methylation status of histone lysine residues. To investigate the specificity and mode of action of DZNeP, zebrafish embryos displaying high histone methyltransferase activity were cultured with DZNeP and histone methylation (H3K4m...
ORGANISM(S): Danio rerio 
2014-11-21 | E-GEOD-53209 | biostudies-arrayexpress
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