C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin fa...
This model represents a set of generic, commonly expressed receptor signaling pathways, including EGFR, G-protein-coupled receptor (alpha i, alpha q, alpha 12/13, and alpha s ligands), integrin, and stress pathways.
