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ProteomicsMechanism of mitoribosomal small subunit biogenesis and preinitiation
Mitoribosomes are essential for synthesis and maintenance of bioenergetic proteins. Here, we use cryoelectron microscopy (cryo-EM) to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with auxiliary factors, revealing a sequential assembly mechanism. The methyltran...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD031678 | Pride
Silac Sucrose gradient Translation initiation Mitoribosome 
ProteomicsHuman GTPBP5 is involved in the late stage of mitoribosome large subunit assembly
Human mitoribosomes are macromolecular complexes essential for translation of 11 mitochondrial mRNAs. The large and the small mitoribosomal subunits undergo a multistep maturation process that requires the involvement of several factors. Among these factors, GTP-binding proteins (GTPBPs) play an imp...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD017384 | Pride
Mitochondria Silac Lfq 
ProteomicsHuman mitochondria require mtRF1 for translation termination at non-canonical stop codons
Mitochondrial translation system highly diverged from its bacterial counterpart. This includes deviation from the universal genetic code, with AGA and AGG having no cognate tRNAs in human mitochondria. Their locations at the end of COX1 and ND6 open reading frames, respectively, suggests they functi...
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD034342 | Pride
Mtrf1 Tmt Mitochondria Translation 
ProteomicsDistinct roles for human mtIF2 and mtIF3 in non-canonical mitochondrial translation
The production of mitochondrial OXPHOS complexes is central to cellular metabolism, although the molecular details of mitochondrial translation remain enigmatic. It is widely held that translation initiation in human mitochondria proceeds similarly to bacterial systems, with mRNA binding t...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD021015 | Pride
Lfq Initiation Mitochondrial Translation 
ProteomicsGTPBP8 is essential for mitoribosome formation in human mitochondria
Mitochondrial gene expression relies on mitoribosomes to translate mitochondrial mRNAs. The biogenesis of mitoribosomes is an intricate process involving multiple assembly factors. Among these factors, GTP-binding proteins (GTPBPs) play crucial roles. In bacterial systems, numerous GTPBPs are requir...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD045264 | Pride
Mitoribosome Gtpbp8 
UnknownRMND1 dysfunction causes OXPHOS deficiency and alters mitoribosomal protein homeostasis in vivo
Not available
S-SCDT-10_1038-S44321-026-00534-1 | biostudies-other
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