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TranscriptomicsTranscription profiling of mouse embryonic stem (ES) cells exposed to oxidative stress
Elevated reactive oxidative species (ROS) may be crucial for cellular transformation and tumor progression. Defining the response of stem cells to ROS is critical to understanding the unique sensitivity of stem cells to ROS-mediated transformation and tumor initiation. We examined both the immediate...
ORGANISM(S): Mus musculus 
2009-11-10 | E-GEOD-18708 | biostudies-arrayexpress
TranscriptomicsTemporal Changes in Rat Liver Gene Expression after Acute Cadmium and Chromium Exposure
U.S. Service Members and civilians are at risk of exposure to a variety of environmental health hazards throughout their normal duty activities and in industrial occupations. Metals are widely used in large quantities in a number of industrial processes and are a common environmental toxicant, which...
ORGANISM(S): Rattus norvegicus 
2015-05-21 | E-GEOD-65198 | biostudies-arrayexpress
ProteomicsRoot isoprene formation alters lateral root development Maja Miloradovic van Doorn
Isoprene is a C5 volatile organic compound, which can protect aboveground plant tissue from abiotic stress such as short-term high temperatures and accumulation of reactive oxygen species (ROS). Here, we uncover new roles for isoprene in the plant belowground tissues. By analyzing Populus x canescen...
ORGANISM(S): Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) 
2020-06-16 | PXD019789 | Pride
Populus x canescens  ros  voc  isoprene  isoprene promoter  lateral roots  poplar  reactive oxygen species  roots  volatile organic compounds. 
UnknownCyclic N, O-acetals and corresponding opened N, N-aminals as new scaffolds with promising anti-inflammatory and antifungal activities against Candida albicans.
Not available
S-EPMC11897400 | biostudies-literature
ProteomicsAccelerated aging modulates the toxicological properties of the diazo tattoo pigment Po13
Pigment particles used in tattooing may exert long terms effect by releasing diffusible degradation products. In the present work, aqueous suspensions of the organic orange pigment Po13 were aged by exposure to simulated sunlight at 40°C. The morphology and the surface charge of Po13 particles were ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056061 | Pride
Tattoo Skin toxicity Nanolc-ms/ms 
ProteomicsIron Toxicity targeting mitochondrial Iron-Sulfur cluster enzymes
Unregulated nutritional iron absorption in hereditary hemochromatosis causes its overload, especially in liver. While this may lead to severe pathology, intriguingly, it may also frequently go unrecognized. Indeed, profound iron loading in hemochromatosis Hfe knockout mice and hemochromatosis Huh7 h...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD070837 | Pride
Iron-sulfur cluster enzymes Mitochondria Hemochromatosis Trace metals Methanobactin Liver Iron overload 
TranscriptomicsAnalysis of the molecular dialogue between gray mold (Botrytis cinerea) and grapevine (Vitis vinifera) reveals a clear shift in defense mechanisms during berry ripening
Mature grapevine berries at the harvesting stage (MB) are very susceptible to the gray mold fungus Botrytis cinerea while veraison berries (VB) are not. We conducted simultaneous microscopic and transcriptomic analyses of the pathogen and the host to investigate the infectious process developed by B...
ORGANISM(S): Vitis vinifera 
2015-08-08 | E-GEOD-65969 | biostudies-arrayexpress
ProteomicsImpaired stability of tumor cells after targeting of lactate/pyruvate metabolism investigated by shotgun proteomics
Overexpression of heat shock proteins (HSPs), especially the major stress-inducible 72 kDa heat shock protein 70 (Hsp70), in malignant tumor cells is associated with therapeutic resistance. The heightened metabolic demand in tumor cells (Warburg effect) increases lactate dehydrogenase (LDH) activity...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026078 | Pride
Lc-msms Heat shock proteins Lactate/pyruvate metabolism Ldha/b double knockout Membrane hsp70 expression Radiosensitivity 
ProteomicsMudPIT analysis of HSV-1 infected and mock-infected microsomal membranes and nuclear envelopes
Nuclear envelopes (NEs) and microsomal membranes (MMs) were isolated from HeLa cells infected or not with HSV-1 using well-established procedures as described in: Wilkie GS, et al. (2011) Mol Cell Proteomics 10: M110 003129. Korfali N, et al. (2010) Mol Cell Proteomics 9: 2571-2585. Florens L, Korf...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Herpes Simplex Virus (type 1 / Strain 17) (ncbitaxon:10299) 
2016-07-05 | MSV000079886 | MassIVE
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
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