Sort   by:  
 Page size 
TranscriptomicsGene expression changes associated with progression of Irf8M-bM-^@M-^S/M-bM-^@M-^S CML-like disease into blast crisis after M-NM-2-catenin activation
Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics, we observed that compound constitutive activation of M-NM-2-catenin and deletion of Irf8 results in progression of CML-like disease into fatal bla...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-49054 | biostudies-arrayexpress
UnknownDose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs.
Not available
S-EPMC10113925 | biostudies-literature
TranscriptomicsTranscriptome-based profiling reveals a macrophage pedigree and identifies Irf8 as pivotal for macrophage homeostasis and function
Recent studies have shown that tissue macrophages (MF) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize the tissues before birth. Further studies have proposed that developmentally distinct tissue MF can be identified based on the differential expression of F4/80 an...
ORGANISM(S): Mus musculus 
2016-07-28 | E-GEOD-73125 | biostudies-arrayexpress
GenomicsTwo distinct auto-regulatory loops operate at the Pu.1 locus in B cells and myeloid cells
The transcription factor PU.1 occupies a central role in controlling myeloid and early B cell development and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. However, little is known of how this tissue-specific pattern is established. ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-26550 | biostudies-arrayexpress
UnknownGFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia.
Not available
S-EPMC9417998 | biostudies-literature
ProteomicsGermline variant GFI1-36N affects DNA repair in AML cells resulting in sensitivity to DNA damage and repair therapy
Transcriptional repressor Growth factor independence 1 (GFI1) is a key regulator of haematopoiesis. We previously established that the germline variant GFI1-36N promotes acute myeloid leukemia (AML) development, however the mechanism is not full elucidated. Here using multi-omics approach, we show G...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037433 | Pride
Gfi1 Gfi1n36 Leukemia Proteome Dna damage and repair Aml 
TranscriptomicsPU.1 restricts adult hematopoietic stem cell proliferation via cell specific autoregulation
To guarantee blood supply throughout adult life hematopoietic stem cells (HSCs) need to carefully balance between self-renewing cell divisions and quiescence. Identification of genes controlling HSC self-renewal is of utmost importance given that HSCs are the only stem cells with broad clinical appl...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33031 | biostudies-arrayexpress
UnknownGerm line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy.
Not available
S-EPMC10733838 | biostudies-literature
Sort   by:  
 Page size