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ProteomicsGFI1 facilitates efficient DNA repair by regulating PRMT1-dependent methylation of MRE11 and 53BP1
GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GF...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008897 | Pride
Dna repair gfi1 prmt1 methylation mre11 53bp1 
ProteomicsSWATH-MS Analysis of Gfi1-mutant bone marrow neutrophils
This study investigates the proteomic alterations in bone marrow neutrophils isolated from 5-8 week old Gfi1+/-, Gfi1K403R/-, Gfi1R412X/-, and Gfi1R412X/R412X mice using the SWATH-MS technique. This dataset consists of 26 raw MS files, comprising 13 DDA (for spectral library generation)and 13 DIA (f...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-07 | PXD010943 | Pride
Scn Gfi1 Swath Neutrophil 
ProteomicsGFI1 tethers the NuRD complex to open and transcriptionally active chromatin in myeloid progenitors
GFI is a DNA binding transcriptional repressor that regulates myeloid differentiation. Here, we show that GFI1 interacts with the chromodomain helicase CHD4 and other components of the nucleosome remodeling and deacetylase (NuRD) complex. Our data demonstrated that GFI1 and GFI1/CHD4 complexes occup...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD028945 | Pride
Gfi1 Myeloid differentiation Nurd complex Chromatin 
TranscriptomicsmicroRNA expression in bone marrow cells from Gfi1 deficient mice
Growth factor independent-1 (Gfi1) is a zinc finger transcription factor with a SNAG amino-terminal repressor domain and is critically required for normal myelopoesis. Gfi1 is normally expressed in HSCs and induced during differentiation from CMPs to GMPs. Gfi1 loss-of-function mutation in mice and ...
ORGANISM(S): Mus musculus 
2009-03-10 | E-GEOD-15077 | biostudies-arrayexpress
GenomicsTrancriptomic analysis of leukemic bone marrow cells with GFI1 wildtype, GFI1 SNP variant (GFI1-36N) and low level of GFI1 expression
Trancriptomic analysis of leukemic bone marrow cells with GFI1 wildtype, GFI1 SNP variant (GFI1-36N) and low level of GFI1 expression
PRJNA802740 | ENA
TranscriptomicsTranscription profiling of mouse T-cells from wildtype and Gfi1 knockout mice
This SuperSeries is composed of the following subset Series:; GSE4938: murine CD4+ and CD8+ T-cells from wildtype and Gfi knockout cells; GSE4940: murine T-cells from wildtype and Gfi1 knockout mice activated by anti-CD3 plus anti-CD28 for 0 to 24h Experiment Overall Design: Refer to individual Seri...
ORGANISM(S): Mus musculus 
2009-08-07 | E-GEOD-4950 | biostudies-arrayexpress
TranscriptomicsMouse ILC2 cells from wild-type or Gfi1-KO animals
Innate type-2 lymphocytes (ILC2s) are a newly described cell type whose biology and contribution to disease are poorly understood. We are interested in investigating the role of the transcription factor Gfi1 in ILC2s, which appear to be a prominent source of IL-5 and IL-13 during type-2 immune respo...
ORGANISM(S): Mus musculus 
2013-10-20 | E-GEOD-45621 | biostudies-arrayexpress
ProteomicsGermline variant GFI1-36N affects DNA repair in AML cells resulting in sensitivity to DNA damage and repair therapy
Transcriptional repressor Growth factor independence 1 (GFI1) is a key regulator of haematopoiesis. We previously established that the germline variant GFI1-36N promotes acute myeloid leukemia (AML) development, however the mechanism is not full elucidated. Here using multi-omics approach, we show G...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037433 | Pride
Gfi1 Gfi1n36 Leukemia Proteome Dna damage and repair Aml 
GenomicsGfi1 knockout in Raw264.7 macrophages
Gfi1 knockout in Raw264.7 macrophages
PRJNA640669 | ENA
TranscriptomicsTranscription profiling of naive CD4+ and CD8+ T-cells from Gfi1-knockout and wild type mice
to compare the transcriptomes of naïve CD4+ and CD8+ T-cells from Gfi1-knockout cells with wildtype cells, spleenocytes from wildtype and Gfi-knockout C57Bl/6 mice were isolated, stained with CD44, CD4 and CD8 antibodies and separated by using a FACS Diva (Becton Dickinson). Total RNAs isolated fr...
ORGANISM(S): Mus musculus 
2008-10-17 | E-GEOD-4938 | biostudies-arrayexpress
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