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Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
The act of surgery strongly stimulated breast cancer cell growth in mice. Local irradiation of wounded breast efficiently prevented wounded-induced breast cancer cell growth. These modifications were linked to miR modulation both in human specimens and in the mouse model, in vivo. The most significa...
ORGANISM(S): Homo sapiens 
This project contains mass spectrometry-based proteomics data from the human induced pluripotent stem cell reference line KOLF2.1J in the undifferentiated state and following directed differentiation into endoderm, ectoderm, and mesoderm. Biological triplicates were analyzed for each condition. The ...
ORGANISM(S): Homo Sapiens 
Although desert dust is known to cause increased respiratory morbidity and mortality, the underlying biological pathways remain unclear. We used RNA-seq on an advanced human alveolar in vitro model to find yet unidentified genes dysregulated by Saharan dust exposure. For comparison, DQ12 quartz dust...
ORGANISM(S): Homo sapiens 
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