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MetabolomicsSerum Predose Metabolic Profiling For Prediction Of Rosuvastatin Pharmacokinetic Parameters In Healthy Volunteers
Rosuvastatin is a quite known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery diseases prevention. There is substantial inter-individual variability in the absorption of statins usually caused by genetic polymorphisms leading to variation in the correspondi...
2021-10-29 | MTBLS3128 | MetaboLights
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform]
With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24187 | biostudies-arrayexpress
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome
This SuperSeries is composed of the following subset Series: GSE24186: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform] GSE24187: Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix pla...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24188 | biostudies-arrayexpress
TranscriptomicsAtorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform]
With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well ...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-24186 | biostudies-arrayexpress
ProteomicsEffect of Rosuvastatin on the Lipoprotein Proteome
Statins lower plasma cholesterol by as much as 50%, thus reducing future cardiovascular events. However, the physiological effects of statins are diverse and not all are related to LDL-C lowering. We performed a small clinical pilot study to assess the impact of statins on lipoprotein-associated pro...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002633 | Pride
Lipoprotein Rosuvastatin Ldl Statin Hdl 
TranscriptomicsComparative Effects of Statins on Murine Cardiac Gene Expression Profiles in Normal Mice
Recent clinical data suggest that the efficacy of statin treatment in patients with heart failure varies depending on the drugs administered. Therefore, the present study was undertaken to compare murine cardiac gene expression following treatment with four different statins. Statins directly regula...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-23101 | biostudies-arrayexpress
TranscriptomicsSystems biology analysis unravels complementary action of combined Rosuvastatin and Ezetimibe therapy
Transcriptomics analysis to understand both efficacy and side effects of a cholesterol lowering drug combination therapy based on biological pathways and molecular processes affected by each drug alone or in combination. We have treated ApoE*3Leiden mice, a humanized atherosclerosis model with a uni...
ORGANISM(S): Mus musculus 
2013-02-27 | E-GEOD-38688 | biostudies-arrayexpress
TranscriptomicsEffect of TCPOBOP, PCN, rosuvastatin, and atorvastatinin on cholesterol homeostasis
This SuperSeries is composed of the following subset Series: GSE13688: Effect of TCPOBOP and PCN in combination with high-cholesterol diet on genes involved in cholesterol homeostasis GSE13689: Effect of rosuvastatin and atorvastatin in combination with high-cholesterol diet on cholesterol homeostas...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-13721 | biostudies-arrayexpress
GenomicsTherapeutic effects of Rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor
Therapeutic effects of Rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor
PRJNA435983 | ENA
TranscriptomicsTherapeutic effects of Rosuvastatin in hypercholesterolemic prediabetic mice in the absence of low density lipoprotein receptor
Statins are efficient in preventing cardiovascular disease progression, but their effects in the absence of low density lipoprotein receptor (LDLR) and on the risk of diabetes are not yet well characterized. The aim was to clarify systemic and pleiotropic effects of Rosuvastatin on cardiovascular an...
ORGANISM(S): Mus musculus 
2018-11-23 | GSE111125 | GEO
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