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MetabolomicsGenomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep
Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon rel...
2017-07-14 | MTBLS322 | MetaboLights
MetabolomicsPostoperative Exercise Modulating Gut Microbiota and Associated Metabolites to Facilitate Bone-Tendon Healing in Rotator Cuff Tears

Background: Rotator cuff tear (RCT) is a prevalent shoulder injury, and postoperative exercise is considered to facilitate RCT healing. However, the effect of postoperative exercise on RCT healing through gut microbiota and metabolites remains unclear.

Method: The control (con) group (n=10...

2026-03-03 | MTBLS13894 | MetaboLights
MetabolomicsRat Rotator Cuff Lipidomics
Not available
ORGANISM(S): Rattus norvegicus 
ST000666 | MetabolomicsWorkbench
ProteomicsLactylation omics of rabbit rotator cuff tears
In this study, we conducted lactylation omics on rabbit rotator cuff tear samples and identified 2624 modification sites on 851 proteins. We obtained results on modification intensity, subcellular localization, modified sites, differentially modified proteins and functional pathway enrichment. Basin...
ORGANISM(S): Leporidae 
2026-04-06 | PXD062718 | Pride
Lactate  lactylation  omics 
ProteomicsProteomic Analysis of Full-Thickness Rotator Cuff Tears: Potential Role of Tetranectin in Synovial Fluid
Rotator cuff tears are one of the most common shoulder disorders and can lead to pain, weakness, and limited mobility. Although the clinical condition has been widely studied, its molecular mechanisms are still not fully understood. In this study, we analyzed the proteomic profile of synovial fluid ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD064264 | Pride
Full-thickness rotator cuff tears Synovial fluid Proteomics Tetranectin 
GenomicsTranscriptional Changes Associated with rotator cuff repair
Transcriptional Changes Associated with rotator cuff repair
PRJNA773394 | ENA
ProteomicsThe role of the bursa in rotator cuff disease.
Rotator cuff injuries result in over 500,000 surgeries performed annually, an alarmingly high number of which fail. These procedures typically involve repair of the injured tendon and removal of the subacromial bursa. However, recent identification of a resident population of mesenchymal stem cells ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD043481 | Pride
Supraspinatus Rotator cuff Tendon Subacromial bursa Tendinopathy 
ProteomicsData in support of TNF inhibition in experimental rotator cuff tear mouse model
Musculoskeletal injuries related to the rotator cuff (RC) are frequent and account for up to 70% of shoulder pain problems. Lesions of the RC lead to weakness and pain (ref: Carr et al mfl) and untreated these lesions are acompanied by muscle degeneration modulated by inflammatory reactions that var...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD035331 | Pride
Proteomics Rotator cuff Mouse 
ProteomicsDefective Mitochondrial Lipid Oxidation Results in the Pathological Accumulation of Fat After Rotator Cuff Tear
Myosteatosis, also known as fatty infiltration, is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following rotator cuff injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-04-15 | PXD009034 | Pride
Short chain fatty acids Lipidomics Mitochondrial dysfunction Rotator cuff injury Skeletal muscle 
TranscriptomicsRat Rotator Cuff Tear RNASeq
Myosteatosis is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following skeletal muscle injury or disease. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree of lipid infiltratio...
ORGANISM(S): Rattus norvegicus 
2018-08-29 | GSE103266 | GEO
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