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Chronic tendon injuries, also known as tendinopathy, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure and yet little is known about the molecular mechanism leading to tendinopathy. We have used histologi...
ORGANISM(S): Homo sapiens 
Overuse injuries of tendon (tendinopathy) represents a significant musculoskeletal health problem, but its pathogenesis is only sparsely understood. We investigated the characteristics behind the development of tendinopathy in humans that had either early phase (1-2 months of symptoms, n=14) (ET) or...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD062414 | Pride
Participants with unilateral patellar tendinopathy and symptoms lasting three months or less were recruited. Biopsies were taken from the proximal regions of the tendinopathic and contralateral patellar tendons. Proteins were isolated, digested, and prepared for data-independent acquisition liquid-c...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD071372 | Pride
A single-cell multi-modal ATAC + gene expression sequencing in tendinopathy
CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition [array]
Chronic tendon injuries, also known as tendinopathy, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure and yet little is known about the molecular mechanism leading to tendinopathy. We have used histologica...
ORGANISM(S): Homo sapiens 
2011-06-07 | GSE26051 | GEO
CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition [seq]
As people become more motivated to exercise regularly and stay healthy, tendinopathy is a common problem in both active athletes and inactive individuals, which imposes a considerable social and economic burden. Here we provide a single-cell multi-modal ATAC + gene expression sequencing in tendinopa...
ORGANISM(S): Homo sapiens 
2023-05-31 | GSE213803 | GEO
Tendinopathy, the most common disorder affecting tendons, is characterized by chronic disorganization of the tendon matrix, which eventually leads to tendon tear and rupture. The goal of this study was to identify a rational molecular target whose blockade can serve as a potential therapeutic interv...
ORGANISM(S): Mus musculus 
2021-10-02 | GSE180368 | GEO
Tendinopathy, the most common disorder affecting tendons, is characterized by chronic disorganization of the tendon matrix, which eventually leads to tendon tear and rupture. The goal of this study was to identify a rational molecular target whose blockade can serve as a potential therapeutic interv...
ORGANISM(S): Mus musculus 
2021-10-02 | GSE181172 | GEO
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