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MetabolomicsPostoperative Exercise Modulating Gut Microbiota and Associated Metabolites to Facilitate Bone-Tendon Healing in Rotator Cuff Tears

Background: Rotator cuff tear (RCT) is a prevalent shoulder injury, and postoperative exercise is considered to facilitate RCT healing. However, the effect of postoperative exercise on RCT healing through gut microbiota and metabolites remains unclear.

Method: The control (con) group (n=10...

2026-03-03 | MTBLS13894 | MetaboLights
ProteomicsLactylation omics of rabbit rotator cuff tears
In this study, we conducted lactylation omics on rabbit rotator cuff tear samples and identified 2624 modification sites on 851 proteins. We obtained results on modification intensity, subcellular localization, modified sites, differentially modified proteins and functional pathway enrichment. Basin...
ORGANISM(S): Leporidae 
2026-04-06 | PXD062718 | Pride
Lactate  lactylation  omics 
GenomicsTranscriptional Changes Associated with rotator cuff repair
Transcriptional Changes Associated with rotator cuff repair
PRJNA773394 | ENA
ProteomicsDefective Mitochondrial Lipid Oxidation Results in the Pathological Accumulation of Fat After Rotator Cuff Tear
Myosteatosis, also known as fatty infiltration, is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following rotator cuff injury. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-04-15 | PXD009034 | Pride
Short chain fatty acids Lipidomics Mitochondrial dysfunction Rotator cuff injury Skeletal muscle 
ProteomicsThe role of the bursa in rotator cuff disease.
Rotator cuff injuries result in over 500,000 surgeries performed annually, an alarmingly high number of which fail. These procedures typically involve repair of the injured tendon and removal of the subacromial bursa. However, recent identification of a resident population of mesenchymal stem cells ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD043481 | Pride
Supraspinatus Rotator cuff Tendon Subacromial bursa Tendinopathy 
TranscriptomicsRat Rotator Cuff Tear RNASeq
Myosteatosis is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following skeletal muscle injury or disease. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree of lipid infiltratio...
ORGANISM(S): Rattus norvegicus 
2018-08-29 | GSE103266 | GEO
GenomicsTranscriptomic profiling of rat supraspinatus muscle after tissue-adaptive flexible ultrasound patch treatment in a rotator cuff injury model
Transcriptomic profiling of rat supraspinatus muscle after tissue-adaptive flexible ultrasound patch treatment in a rotator cuff injury model
PRJNA1466930 | ENA
GenomicsThe subacromial bursa regulates rotator cuff tendon healing and is a target to augment tendon repair.
The subacromial bursa regulates rotator cuff tendon healing and is a target to augment tendon repair.
PRJNA987719 | ENA
TranscriptomicsTranscriptomic profiling of rat supraspinatus muscle after tissue-adaptive flexible ultrasound patch treatment in a rotator cuff injury model
Rotator cuff tear is frequently accompanied by progressive supraspinatus muscle degeneration, including muscle atrophy, fibrosis, fatty infiltration and inflammatory remodeling. In this study, we performed bulk RNA sequencing to investigate the transcriptional effects of a tissue-adaptive flexible u...
ORGANISM(S): Rattus norvegicus 
2026-05-31 | GSE331125 | GEO
GenomicsTranscriptional Changes Associated with Acute to Chronic Stage Muscle Adaptations in a Model of Rotator Cuff Tendon Tear
Transcriptional Changes Associated with Acute to Chronic Stage Muscle Adaptations in a Model of Rotator Cuff Tendon Tear
PRJNA724734 | ENA
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