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TranscriptomicsTranscription profiling of strains of Paxillus involutus that show different abilities in formation of ectomycorrhizal associations with birch (Betula pendula)
A microarray analysis was conducted to investigate transcriptional differences between strains of Paxillus involutus that show different abilities in formation of ectomycorrhizal associations with birch (Betula pendula). Our goal was to identify genes that showed differential regulation from compari...
ORGANISM(S): Ectomycorrhizal tissue: Paxillus involutus/Betula pendula 
2004-10-05 | E-MEXP-179 | biostudies-arrayexpress
ModelsBoehm2014 - isoform-specific dimerization of pSTAT5A and pSTAT5B
Boehm2014 - isoform-specific dimerization of pSTAT5A and pSTAT5B To study STAT5 activation, the authors build a dynamic model of pSTAT5 isoform dimerization. Combinatorial binding of pSTAT5A and pSTAT5B is analysed using model hypotheses and concurrent experiments. Model parameters are derived from ...
2024-09-02 | BIOMD0000000591 | BioModels
ProteomicsMyxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis
Fidaxomicin is considered the current gold standard antibiotic for treating Clostridioides difficile infections and kills bacterial cells by inhibition of the RNA polymerase through binding to its switch region. Although binding sites do not overlap, also Myxopyronin B inhibits the RNA polymerase by...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-12-21 | PXD027366 | Pride
Clostridioides difficile Rna polymerase inhibitors Fidaxomicin Rifaximin Toxins Antibiotic resistance Antibiotic therapy Myxopyronin b 
ProteomicsThe proteomic response of Clostridioides difficile to the Chlorotonil A derivative ChtB1-Epo2
The anaerobic, spore-forming pathogen Clostridioides difficile infects the gastrointestinal tract of higher mammals, including humans, and is the major causative agent of antibiotic-associated diarrhea. Moreover, recurrence and re-infection rates after a first successful antibiotic therapy are subst...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2023-03-29 | PXD029243 | Pride
Chlorotonil a Clostridioides difficile Antibiotic resistance Antibiotic therapy Colonization resistance Selectivity 
ProteomicsThe proteomic response of Clostridioides difficile to the atypical tetracycline amidochelocardin and concomitant dissipation of its proton motive force
Amidochelocardin is an atypical tetracycline which was previously shown to target the bacterial cell membrane although its detailed mode-of-action is still unknown. To gain insight into Clostridioides difficile’s response to membrane targeting antibiotics and to further study the mode-of-action of A...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-08-04 | PXD029250 | Pride
Clostridioides difficile Amidochelocardin Tetracycline Antibiotic resistance Phenazine biosynthesis Antibiotic therapy Dissipation of the proton motive force 
ProteomicsFlavodoxin Landscape in Clostridioides difficile
C. difficile infections have become a major challenge in medical facilities today. The bacterium is capable of spore formation, which even allows survival of antibiotic treatment. Therefore, research on the physiology of C. difficile is important for the development of alternative treatment strategi...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2024-02-02 | PXD041951 | Pride
Expression profiling Mass spectrometry Parallel reaction monitoring 
TranscriptomicsTHOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation
THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation, thereby playing a key role in the mRNA export of immediate early genes induced by CSF-1 stimulation. Hematopoiesis, growth, differentiation, and commitment...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-41170 | biostudies-arrayexpress
TranscriptomicsPhenocopy
Comprehensive in vitro expression profiling of small chemical compound inhibitors of TGFbR1 kinase activity. Additional file E-MTAB-265.additonal.1.zip contains excel file with Taqman data validating the array normalization method
ORGANISM(S): Homo sapiens 
2010-09-14 | E-MTAB-265 | biostudies-arrayexpress
TranscriptomicsRetinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro
Wilms tumor (WT) is one of the most common malignancies in childhood. With current therapy protocols up to 90 % of patients can be cured, but there is still a need to improve therapy for patients with aggressive WT and to reduce treatment intensity where possible. Prior data suggested deregulation o...
ORGANISM(S): Homo sapiens 
2012-04-20 | E-GEOD-28807 | biostudies-arrayexpress
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