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TranscriptomicsEffects of RGMc on BMP2 and BMP6-mediated Gene Expression in Hep3B Liver Cells
Mutations in repulsive guidance molecule c (RGMc) / hemojuvelin (HJV) cause juvenile hemochromatosis, an aggravated iron overload disorder that presents early in life. Patients with juvenile hemochromatosis, and RGMc knockout mice, have diminished expression of the key iron-regulatory peptide, hepc...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-20671 | biostudies-arrayexpress
ProteomicsMouse myoblast fusion - Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190
The p38 MAP kinases play critical roles in skeletal muscle biology, but the specific processes that they regulate remain poorly defined. Here we find that activity of p38α/β is important not only for early phases of myoblast differentiation, but also in later stages of myocyte fusion and myofibrill...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002413 | Pride
Mouse Myoblast Differentiation Fusion 
TranscriptomicsTranscription profiling of mouse C2AS12 cells infected with (1) wt p300 + tTA, (2) p300deltaTAZ2 +tTA, (3) wt p300 +tTA +doxycycline to define the transcriptional network regulated by ectopic expression of the transcriptional co-activator protein, p300 and define its role in promoting muscle cell survival
The primary focus of these studies is to define the transcriptional network regulated by ectopic expression of the transcriptional co-activator protein, p300, in order to define its mechanism(s) of action in promoting muscle cell survival. Our laboratory has generated a murine C2-derived myoblast ce...
ORGANISM(S): Mus musculus 
2007-12-07 | E-GEOD-4224 | biostudies-arrayexpress
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