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TranscriptomicsGenomic mapping of Six1 binding sites during skeletal myoblast differentiation
In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 3 different timepoints to perform ChIP-on-Chip of Six1, which is a key muscle regulator. We identified global loci bo...
ORGANISM(S): Mus musculus 
2010-07-05 | E-GEOD-20150 | biostudies-arrayexpress
TranscriptomicsWnt signaling involved in mouse myoblast differentiation
Wnt/M-NM-2-catenin signaling is involved in various aspects of skeletal muscle development and regeneration. In addition, Wnt3a and M-NM-2-catenin are required for muscle-specific gene transcription in embryonic carcinoma cells and satellite-cell proliferation during adult skeletal muscle regenerati...
ORGANISM(S): Mus musculus 
2011-07-15 | E-GEOD-30077 | biostudies-arrayexpress
ProteomicsMouse myoblast fusion - Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190
The p38 MAP kinases play critical roles in skeletal muscle biology, but the specific processes that they regulate remain poorly defined. Here we find that activity of p38α/β is important not only for early phases of myoblast differentiation, but also in later stages of myocyte fusion and myofibrill...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002413 | Pride
Mouse Myoblast Differentiation Fusion 
Transcriptomicsc-Myb inhibits myoblast fusion
The study of the effects of modification of c-Myb expression on differenatiation of C2C12 cells
ORGANISM(S): Mus musculus 
2013-10-21 | E-MTAB-1376 | biostudies-arrayexpress
ProteomicsMachine learning inference of continuous single-cell state transitions during myoblast differentiation and fusion
Cells dynamically change their internal organization via continuous cell state transitions to mediate a plethora of physiological processes. Understanding such continuous processes is severely limited due to a lack of tools to measure the holistic physiological state of single cells undergoing a tra...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047198 | Pride
Machine learning Differentiation Myoblast 
ProteomicsProtein synthesis during myoblast differentiation
Mole (MSR) and fractional (FSR) synthesis rates of proteins during C2C12 myoblast differentiation were investigated. Myoblast cultures supplemented with D2O during 0-24 h or 72-96 h of differentiation were analysed by LC-MS/MS to calculate protein FSR and MSR after samples were spiked with yeast alc...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021125 | Pride
C2c12  muscle  fractional synthesis rate 
TranscriptomicsRNA-seq comparison of immortalised myoblasts from dystrophic and WT mice
Pathophysiology of Duchenne Muscular Dystrophy (DMD) is still elusive. Although progressive damage to muscle fibres is a cause of muscle deterioration leading to premature death, there is a growing body of evidence indicating that the triggering effects of DMD mutation are present at the very early ...
ORGANISM(S): Mus musculus 
2019-10-02 | E-MTAB-7287 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse strain C2C12 mRNAs and noncoding RNAs during myoblast differentiation
This experiment compared the expression of mRNAs and noncoding RNAs during myoblast differentiation. The primary aim of the experiment was to identify ncRNAs that were differentially expressed during myotube formation.
ORGANISM(S): Mus musculus 
2008-12-01 | E-TABM-575 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila myoblasts from wild type embryos and twelve genotypes in which myogenesis was selectively perturbed to determine the molecular identities of distinct myoblast subpopulations
An important but largely unmet challenge in understanding the mechanisms that govern formation of specific organs is to decipher the complex and dynamic genetic programs exhibited by the diversity of cell types within the tissue of interest. Here, we use an integrated genetic, genomic and computati...
ORGANISM(S): Drosophila melanogaster 
2007-08-14 | E-GEOD-3854 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human 293FT-human embryonic kidney cells, undifferentiated FM95-14 myoblast, and differentiated myoblast to verify FM95-14 expression
Undifferentiated FM95-14 human embryonic myoblasts contain myogenic stem/progenitor cells. Gene expression analysis and comparison to FM95-14 cells that have been allowed to differentiate will allow the ascertainment of genes that are implicated in myogenic lineage commitment. Human myoblast were al...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-10435 | biostudies-arrayexpress
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