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ProteomicsUnfolded Protein Response governs an Alternative Splicing program conserved from healthy to malignant cells
The unfolded protein response (UPR) is a critical adaptive program triggered upon cellular stresses that profoundly reshapes the transcriptome and translatome. In the very first minutes of cellular stress, translation blockage, RNA decay and RNA granules formation prompt the synthesis of proteins es...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD046476 | Pride
Perk Er stress Alternative splicing Unfolded protein response Translation 
UnknownDifferent Motile Behaviors of Human Hematopoietic Stem versus Progenitor Cells at the Osteoblastic Niche.
Not available
S-EPMC4649139 | biostudies-literature
UnknownNuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.
Not available
S-EPMC5511106 | biostudies-literature
ProteomicsPhosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landsc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032980 | Pride
Aml Phosphoproteomics Genomics Kmt2a Impdh Drug screen Nucleolus Proteomics 
UnknownMyelodysplastic syndrome can propagate from the multipotent progenitor compartment.
Not available
S-EPMC5210239 | biostudies-literature
UnknownAdaptive from Innate: Human IFN-γ<sup>+</sup>CD4<sup>+</sup> T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults.
Not available
S-EPMC5563168 | biostudies-literature
UnknownCRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny.
Not available
S-EPMC10450654 | biostudies-literature
UnknownSF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment.
Not available
S-EPMC4686651 | biostudies-literature
UnknownThe combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.
Not available
S-EPMC5698422 | biostudies-literature
UnknownA niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms.
Not available
S-EPMC3973718 | biostudies-literature
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