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Male fertility and testis function changes with age and so it was sought to determine if these changes are accompanied by changes in gene expression. A full genome microarray was used to determine if distinct pathways of genes were altered in expression in germ cells (pachytene spermatocytes or roun...
ORGANISM(S): Rattus norvegicus 
Mouse Round Spermatids (Sptd) and Pachytene Spermatocytes (Spcy)
ORGANISM(S): Mus musculus 
The proteome changes were quantified in Ck137956-/- mouse round spermatids using TMT 6-plex by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2023-04-01 | PXD036804 | Pride
Brdt is a testis specific member of a family of chromatin interacting proteins. All of the family members have been shown to regulate transcription. Brdt is highly expressed in round spermatids, and may play a role in transcriptional regulation in these cells. We investigated transcriptional changes...
ORGANISM(S): Mus musculus 
Investigation of a new RNA-modification-based mechanism in mammalian spermatogenesis. We created a mice line devoid of testis-specific m5C RNA methyltransferase Nsun7. These mice demonstrated male infertility due to a peculiar defect in sperm tail assembly – mispositioning of the longitudinal column...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD067398 | Pride
miRNA expression profiles for round spermatids of wild type and GRTH knock-out mice were determined by Rodent TaqMan® Low Density miRNA Arrays A v2.0 (TLDA, Applied Biosystem). Purified round spermatids were prepared from the testis of wild type and GRTH null mice (C57BL/6 strain). Equal amount of ...
ORGANISM(S): Mus musculus 
Here we performed target proteomics of NSUN7 on sorted elongated and round spermatids, as well as mature spermatozoa. We showed that NSUN7 is present at all stages of spermiogenesis and is most abundant in round spermatids, which corresponds to the formation of flagellum and fibrous sheath assembly.
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD069148 | Pride
Quantitative analysis of wild type, MiwiΔIns and MiwiR371W round spermatids transcriptomes
Microarray analysis of purified pachytene spermatocytes and round spermatids. Each stage was examined in wild type and RNF8 knockout mice in two biological replicates. We performed microarray analysis using Affymetrix Gene 1.0 ST Arrays with purified pachytene spermatocytes and round spermatids. Pac...
ORGANISM(S): Mus musculus 
Effect of aging on gene expression in round spermatids from Brown Norway rats
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