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ProteomicsProteome of wild type and Nsun7 knockout mice round spermatids
Investigation of a new RNA-modification-based mechanism in mammalian spermatogenesis. We created a mice line devoid of testis-specific m5C RNA methyltransferase Nsun7. These mice demonstrated male infertility due to a peculiar defect in sperm tail assembly – mispositioning of the longitudinal column...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD067398 | Pride
Nsun7 Spermatogenesis Round spermatids Longitudinal columns Methyltransferase 
ProteomicsProteome of wild type and Nsun7 knockout mice elongated spermatids
Investigation of a new RNA-modification-based mechanism in mammalian spermatogenesis. We created a mice line devoid of testis-specific m5C RNA methyltransferase Nsun7. These mice demonstrated male infertility due to a peculiar defect in sperm tail assembly – mispositioning of the longitudinal column...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD067394 | Pride
Nsun7 Elongated spermatids Spermatogenesis Longitudinal columns Methyltransferase 
ProteomicsEpigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggest that the epitranscriptome and its associated enzymes are altered in human tumors. In this study, the initial screening for genetic and epigenetic defects of 5-methylcytosine RNA methyl...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038418 | Pride
Peaks Snu cells Nsun7 Tmt16plex Methyltransferase 
ProteomicsProteome of wild type and Nsun7 knockout mice spermatozoa
Investigation of a new RNA-modification-based mechanism in mammalian spermatogenesis. We created a mice line devoid of testis-specific m5C RNA methyltransferase Nsun7. These mice demonstrated male infertility due to a peculiar defect in sperm tail assembly – mispositioning of the longitudinal column...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD067410 | Pride
Spermatozoa Nsun7 Spermatogenesis Longitudinal columns Methyltransferase 
ProteomicsProteome of wild type and Nsun7 knockout mice testis
Investigation of a new RNA-modification-based mechanism in mammalian spermatogenesis. We created a mice line devoid of testis-specific m5C RNA methyltransferase Nsun7. These mice demonstrated male infertility due to a peculiar defect in sperm tail assembly – mispositioning of the longitudinal column...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-07 | PXD057007 | Pride
Testis Nsun7 Spermatogenesis Longitudinal columns Methyltransferase 
ProteomicsEvaluation of NSUN7 amount in spermatozoa, round and elongated spermatids of mice
Here we performed target proteomics of NSUN7 on sorted elongated and round spermatids, as well as mature spermatozoa. We showed that NSUN7 is present at all stages of spermiogenesis and is most abundant in round spermatids, which corresponds to the formation of flagellum and fibrous sheath assembly.
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD069148 | Pride
Nsun7 Spermatogenesis 
ProteomicsEpigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggest that the epitranscriptome and its associated enzymes are altered in human tumors. In this study, the initial screening for genetic and epigenetic defects of 5-methylcytosine RNA methyl...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038422 | Pride
Maxquant Nsun7 Interactome Label free Methyltransferase 
GenomicsNSUN7 is an RNA:m5C catalytically inactive protein that regulates sperm flagellum assembly
NSUN7 is an RNA:m5C catalytically inactive protein that regulates sperm flagellum assembly
PRJNA1264989 | ENA
UnknownNSUN7 Regulates Sperm Flagella Formation at All Stages of Spermiogenesis.
Not available
S-EPMC12785897 | biostudies-literature
GenomicsNSUN7 is an RNA:m5C catalytically inactive protein that regulates sperm flagellum assembly [scRNA-seq]
NSUN7 is an RNA:m5C catalytically inactive protein that regulates sperm flagellum assembly [scRNA-seq]
PRJNA1266728 | ENA
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