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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
MetabolomicsMetabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner
Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that can reduce body weight and obesity-associated morbidity. The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood....
2017-02-10 | MTBLS242 | MetaboLights
MetabolomicsAn untargeted metabolomics approach to characterize short-term and long-term metabolic changes after bariatric surgery
Bariatric surgery is currently one of the most effective treatments for obesity and leads to significant weight reduction, improved cardiovascular risk factors and overall survival in treated patients. To date, most studies focused on short-term effects of bariatric surgery on the metabolic profile ...
2015-09-15 | MTBLS218 | MetaboLights
TranscriptomicsTranscription profiling of rats subjected to Roux-en-Y gastruc bypass to characterize of weight loss and weight regain mechanisms
Roux-en-Y gastric bypass (RYGB) is the most effective therapy for morbid obesity, but it has a ~20% failure rate. We used our established RYGB model in diet-induced obese (DIO) Sprague-Dawley rats, which reproduces human bi-phasic body weight (BW) loss pattern, to determine mechanisms contributing t...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-8314 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle from morbidly obese patients before and after gastric bypass surgery to identify genes responsive to weight loss.
Obesity results from a chronic imbalance between energy intake and energy expenditure, with excess calories stored as fat. As such, weight loss has long been considered as a primary goal of treatment for obesity. A surgical treatment of severe obesity such as gastric bypass provides the most dramati...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5109 | biostudies-arrayexpress
ProteomicsPlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specifi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084344 | MassIVE
ProteomicsFecal Transplant from Roux-Y-Gastric-Bypass rat model into a diet induced obesity rat model
Investigating alterations the intestinal microbiome in a diet induced obesity (DIO) rat model after fecal transplant from rats, which underwent Roux-Y-Gastric-Bypass surgery (RYGB). The microbiomes of the RYGB-donor rats, the DIO rats, and DIO rats after receiving the fecal transplant from the RYGB ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-08-12 | PXD026606 | Pride
Roux-y-gastric bypass surgery Metaproteomics Microbiome Obesity Rat Anti-biotics 
ProteomicsNovel insights on remnant stomach following Roux-en-Y Gastric Bypass surgery based on histological evaluation and quantitative proteomics analysis
Background: Patients undergoing weight-reducing Roux-en-Y gastric bypass (RYGB) have immediate positive effects on metabolic health, including type 2 diabetes (T2D). Refeeding via the secluded stomach, either by a gastrotube or after gastro-gastric fistulation result in T2D relapse and weight regain...
ORGANISM(S): Homo sapiens (Human) 
2025-07-17 | PXD065508 | Pride
Human  proteomic remnant stomach  roux-en-y gastric bypass 
GenomicsGoto-Kakizaki rats with Roux-en-Y gastric bypass surgery
Goto-Kakizaki rats with Roux-en-Y gastric bypass surgery
PRJNA523431 | ENA
TranscriptomicsmiRNA profiling by array of human paired adipose tissue (subcutaneous and omentum) before and after gastric-bypass and weight loss
Objective: Adipose tissue plays a key role in obesity related metabolic dysfunction. MicroRNA (miRNA) are gene regulatory molecules involved in inter-cellular and inter-organ communication. We hypothesised that miRNA levels in adipose tissue would change after gastric bypass surgery and that this wo...
ORGANISM(S): Homo sapiens 
2019-12-16 | E-MTAB-8594 | biostudies-arrayexpress
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