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MetabolomicsSIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
Mitochondrial function relies on the coordinated transcription of mitochondrial and nuclear genomes to assemble respiratory chain complexes. Across species, the SIN3 coregulator influences mitochondrial functions, but how its loss impacts mitochondrial homeostasis and metabolism in the context of a ...
2024-04-01 | MTBLS8439 | MetaboLights
GenomicsNational Eye Institute (NEI) Ocular Hypertension Treatment Study (OHTS)

The Ocular Hypertension Treatment Study (OHTS) is an National Eye Institute-sponsored multi-center, randomized, prospective treatment trial designed to determine whether lowering intraocular pressure (IOP) in individuals with ocular hypertension delays or prevents the development of primary ope...

phs000240.v1.p1 | EGA
UnknownUsing Human 'Personalized' Cybrids to Identify Drugs/Agents That Can Regulate Chronic Lymphoblastic Leukemia Mitochondrial Dysfunction.
Not available
S-EPMC10341973 | biostudies-literature
TranscriptomicsTranscription profiling of Lotus japonicus grown under different salt acclimation regimes
Model legume Lotus japonicus was subjected to non-lethal long-term salinity and profiled at the transcriptomic level. Three independent experiments were performed, testing two experimental designs: a traditional gradual acclimation following a step-wise increase of salt concentration and an initial ...
ORGANISM(S): Lotus japonicus 
2008-07-17 | E-MEXP-1204 | biostudies-arrayexpress
ProteomicsThe anti-Shine-Dalgarno element of 16S rRNA is needed for translation of one gene, rpsU, in Flavobacterium johnsoniae
Bacteroidia ribosomes are “blind” to SD sequences, even though they contain the conserved anti-SD (ASD) element of 16S rRNA. A structure of the Flavobacterium johnsoniae ribosome shows that the 3’ tail of 16S rRNA is sequestered in a pocket formed by bS21, bS18, and bS6 on the 30S platform, explaini...
ORGANISM(S): Flavobacterium johnsoniae 
2026-03-05 | PXD067211 | Pride
Proteomics 16s rrna Flavobacterium johnsoniae Rpsu Lc-ms/ms 
TranscriptomicsmicroRNA profiling of female and male mouse pituitary gland across pubertal transition
The pituitary gland exhibits sex differences in its function. Diseases associated with dysregulation of the pituitary are also sex-biased in prevalence. Previous qPCR profiling of puberty-related genes in the pituitary gland revealed increasingly sex-biased expression of genes profiled across pubert...
ORGANISM(S): Mus musculus 
2022-10-12 | E-MTAB-9460 | biostudies-arrayexpress
ProteomicsProteomic and Phosphoproteomic Analysis of Pediatric Familial Adenomatous Polyposis
Polyps and non-polyp mucosal specimens were harvested from pediatric Familial Adenomatous Polyposis patients. The proteome and phosphoproteome of each sample was then analyzed using the tandem mass tag system on an Orbitrap Eclipse Tribrid mass spectrometer followed by data analysis with MaxQuant, ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD061190 | Pride
Familial adenomatous polyposis Polyps Proteomic Phosphoproteomic Mucosa Tandem mass tag Quantitative proteomics Pediatric 
UnknownDiabetes prevention in the Caribbean using Lifestyle Intervention and Metformin Escalation (LIME): Protocol for a hybrid Type-1 effectiveness-implementation trial using a quasi-experimental study design.
Not available
S-EPMC8095103 | biostudies-literature
UnknownMuc5b is required for airway defence.
Not available
S-EPMC4001806 | biostudies-literature
ProteomicsSurprisal Analysis of Patient-Specific Signaling Networks in TNBC
The present study sought to combine surprisal analysis, utilizing systems-level data to predict unbalanced processes in each patient tumor, with quantitative analysis of tyrosine phosphorylation mediated signaling networks to identify potential therapeutic targets and therapeutic combinations in TNB...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD042640 | Pride
Surprisal analysis Pdx Triple negative breast cancer Phosphoproteomics Passs 
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