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GenomicsOpioid-induced gut microbial disruption leads to gut barrier compromise and sustained systemic inflammation.
Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to play a critical rol...
ORGANISM(S): Mus musculus domesticus 
2016-06-01 | E-MTAB-3722 | biostudies-arrayexpress
GenomicsMorphine treatment leads to temporal modulation of the gut microbiome
Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit long term use. In the current study using a chronic morphine-murine model a longitudinal approach was undertaken to i...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5550 | biostudies-arrayexpress
GenomicsEffect of morphine treatment on microbiome in the context of microbial transplant.
Morphine causes microbial dysbiosis. In this study we focused on restoration of native microbiota in morphine treated mice and looked at the extent of restoration and immunological consequences of this restoration. Fecal transplant has been successfully used clinically, especially for treating C. di...
ORGANISM(S): Mus musculus domesticus 
2016-06-01 | E-MTAB-3723 | biostudies-arrayexpress
GenomicsMorphine treatment induces distinct changes in the gut microbiome at day 3 post treatment
Opioids such as morphine have many beneficial properties as analgesics, however, opioids may induce multiple adverse gastrointestinal symptoms. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut co...
ORGANISM(S): mouse gut metagenome 
2018-04-16 | E-MTAB-5546 | biostudies-arrayexpress
UnknownDifferential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis.
Not available
S-EPMC4759540 | biostudies-literature
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