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ProteomicsChanges in the proteome of platelets from patients with critical progression of COVID-19
Platelets, the smallest cells in human blood known for their role in primary haemostasis, are also able to interact with pathogens and play a crucial role in the immune response. In severe coronavirus disease 2019 (COVID-19) cases, platelets become over-activated, resulting in the release of granule...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041681 | Pride
Proteomics Glucocorticoid re-ceptor Ecmo Inflammation Nfkb Acute-phase proteins Carbonic anhydrase 1 Covid-19 Platelets 
ProteomicsQuality control in quantitative proteomics: a case study for the human CSF proteome
Proteome studies using mass spectrometry (MS)-based quantification is a main approach for the discovery of new biomarkers. However, a number of analytical conditions in front and during MS data acquisition can affect the accuracy of the obtained outcome. Therefore, comprehensive quality assessment o...
ORGANISM(S): Homo sapiens (Human) 
2023-04-12 | PXD037650 | Pride
Cerebrospinal fluid In-solution digestion Proteomics Quality control Mass spectrometry Label-free quantification Fasp 
ProteomicsCavβ2e translocates from the plasma membrane to the nucleus and potentially regulates gene expression
Voltage-gated calcium channels (VGCCs) play a crucial role in various cellular processes. These channels consist of different subunits, including the Cavβ subunit. In this study, our focus was to investigate the molecular mechanisms underlying the nuclear trafficking of a specific Cavβ2 splice varia...
ORGANISM(S): Homo sapiens (Human) 
2025-04-04 | PXD058727 | Pride
Nuclear localization signal Voltage-gated calcium channels Cavβ Plc Cellular signaling Nuclear translocation 
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