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ProteomicsThe unphosphorylated form of the PAQosome core subunit RPAP3 binds ribosomal preassembly complexes to modulate ribosome biogenesis.
The PAQosome (Particle for Arrangement of Quaternary structure) is a twelve-subunit HSP90 co-chaperone involved in the biogenesis of several human protein complexes. Two mechanisms of client selection have previously been identified, namely the selective recruitment of specific adaptors and the diff...
ORGANISM(S): Homo sapiens (Human) 
2022-06-27 | PXD026647 | Pride
Ap-ms Ribosome preassembly factors Rpap3 Ribosome biogenesis Chaperone Ck2 phosphorylation Paqosome 
ProteomicsSILAC APMS analysis of RPAP3 C-term interactome
To get insights into the function of RPAP3, we characterized its partners by performing a proteomic analysis in human cells. We fused the Cterm part of RPAP3 domain to GFP and stably expressed it in HeLa cells using site-specific integration with the Flp-In system. Following differential labeling of...
ORGANISM(S): Homo sapiens (Human) 
2018-06-10 | PXD009518 | Pride
Human Ltq-orbitrap Hela cells Apms Silac 
UnknownThe RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.
Not available
S-EPMC5974087 | biostudies-literature
UnknownRPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.
Not available
S-EPMC5902453 | biostudies-literature
UnknownUnveiling the Role of Sorghum RPAP3 in the Function of R2TP Complex: Insights into Protein Assembly in Plants.
Not available
S-EPMC10458388 | biostudies-literature
UnknownThe interaction between RPAP3 and TRBP reveals a possible involvement of the HSP90/R2TP chaperone complex in the regulation of miRNA activity.
Not available
S-EPMC8887487 | biostudies-literature
UnknownThe HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium.
Not available
S-EPMC8355188 | biostudies-literature
UnknownTarget Identification of the Marine Natural Products Dictyoceratin-A and -C as Selective Growth Inhibitors in Cancer Cells Adapted to Hypoxic Environments.
Not available
S-EPMC6471994 | biostudies-literature
UnknownStructure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone.
Not available
S-EPMC8278493 | biostudies-literature
UnknownChlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly.
Not available
S-EPMC6821370 | biostudies-literature
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