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TranscriptomicsGlobal Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses.
In the intracellular pathogen Brucella spp., the activation of the stringent response, a global regulatory network providing rapid adaptation to a variety of growth-affecting stress conditions such as nutrient deficiency, is essential for replication in the host. A single, bi-functional enzyme Rsh c...
ORGANISM(S): Brucella suis 1330 
2013-07-08 | E-GEOD-44688 | biostudies-arrayexpress
ProteomicsNanobody-mediated modulation of long RSH enzymes Rel and RelA catalysis by restriction of their conformational landscape
Long RSH enzymes, Rel and RelA, are the master regulators of (p)ppGpp alarmone levels in bacteria. Their catalytic activity is governed by transitions between a compact, hydrolysis-competent (HDON) state and an elongated, synthesis-competent (SYNTHON) state. The equilibrium between these states is m...
ORGANISM(S): Escherichia coli 
2026-04-28 | PXD067451 | Pride
Structural biology Rsh enzymes Nanobodies 
TranscriptomicsThe stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression
The stringent response is initiated by rapid (p)ppGpp synthesis, which leads to a profound reprogramming of gene expression in most bacteria. The stringent phenotype seems to be species specific and may be mediated by fundamentally different molecular mechanisms. In Staphylococcus aureus, (p)ppGpp s...
ORGANISM(S): Staphylococcus aureus 
2013-04-05 | E-GEOD-45617 | biostudies-arrayexpress
ProteomicsRepeated sprint training in hypoxia potentiates muscle glycolytic adaptations through S100A protein signaling
Objective: Athletes increasingly engage in repeated sprint training that consists of repeated short all-out effort interspersed by short periods of recovery. When performed in hypoxia (RSH), it may lead to greater training effects than in normoxia (RSN), however the underlying molecular mechanisms r...
ORGANISM(S): Homo sapiens (Human) 
2024-05-05 | PXD040779 | Pride
Exercise Oxphos S100a13 Rsh Glycolysis 
UnknownA binuclear metallohydrolase model for RelA/SpoT-Homolog (RSH) hydrolases.
Not available
S-EPMC11554896 | biostudies-literature
UnknownRSH enzyme diversity for (p)ppGpp metabolism in Phaeodactylum tricornutum and other diatoms.
Not available
S-EPMC6881373 | biostudies-literature
UnknownIdentification of an rsh gene from a Novosphingobium sp. necessary for quorum-sensing signal accumulation.
Not available
S-EPMC2668395 | biostudies-literature
UnknownThe (p)ppGpp Synthetase RSH Mediates Stationary-Phase Onset and Antibiotic Stress Survival in Clostridioides difficile.
Not available
S-EPMC7484180 | biostudies-literature
UnknownIdentification, characterization and expression analysis of wheat RSH family genes under abiotic stress.
Not available
S-EPMC10711091 | biostudies-literature
UnknownA RelA-SpoT homolog (Cr-RSH) identified in Chlamydomonas reinhardtii generates stringent factor in vivo and localizes to chloroplasts in vitro.
Not available
S-EPMC137175 | biostudies-literature
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