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ProteomicsProteomics of Human Hepatoma Huh-7 Cells Treated by Three Multi-RTK Inhibitors
Sorafenib, lenvatinib and regorafenib, the multi-RTK inhibitors with potent anti-angiogenesis effects, are currently therapeutic drugs generally recommended for the patients with advanced hepatocellular carcinoma (HCC). To date, however, there have been no published studies on the mechanism underlin...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034073 | Pride
Huh-7 cells Proteomics Multi-rtk inhibitors 
ProteomicsFeedback circuitry between miR-218 repression and RTK activation in glioblastoma
Receptor tyrosine kinase pathway signalings plays a central role in the growth and progression of glioblastoma, a highly aggressive group of brain tumors. We recently reported that miR-218 repression, an essentially uniform feature of human GBM, directly promotes RTK hyperactivation by increasing th...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD002112 | Pride
Rtk Glioblastoma Stat3 Mir-218 
GenomicsCapicua controls Toll/IL-1 signaling targets independently of RTK regulation
Capicua controls Toll/IL-1 signaling targets independently of RTK regulation
PRJNA413960 | ENA
TranscriptomicsDiverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [copy number]
Deregulated RTK activity has been implicated as a causal leukemogenic factor in the context of molecular aberrations that perturb differentiation in the hematopoietic lineage such as in childhood ALL. A deeper understanding of RTK signaling processes on a system-wide scale will be key in defining cr...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-42054 | biostudies-arrayexpress
TranscriptomicsDiverse phospho-signaling networks mediate RTK dependent growth and survival in childhood ALL [gene expression]
Deregulated RTK activity has been implicated as a causal leukemogenic factor in the context of molecular aberrations that perturb differentiation in the hematopoietic lineage such as in childhood ALL. A deeper understanding of RTK signaling processes on a system-wide scale will be key in defining cr...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-42001 | biostudies-arrayexpress
UnknownFeedback regulation of RTK signaling in development.
Not available
S-EPMC5920792 | biostudies-literature
UnknownRTK signaling modulates the Dorsal gradient.
Not available
S-EPMC3403108 | biostudies-literature
GenomicsDNA Methylation subclass Receptor Tyrosine Kinase II (RTK II) is predictive for seizure development in glioblastoma patients
DNA Methylation subclass Receptor Tyrosine Kinase II (RTK II) is predictive for seizure development in glioblastoma patients
PRJNA779400 | ENA
GenomicsCapicua controls Toll/IL-1 signaling targets independently of RTK regulation
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor that functions downstream of receptor tyrosine kinase (RTK) signaling pathways in a relatively simple switch: in the absence of signaling, Cic represses RTK-responsive genes by binding to nearly invariant sites in DNA, wherea...
ORGANISM(S): Drosophila melanogaster 
2018-01-05 | GSE104839 | GEO
GenomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [ChIP-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-64190 | biostudies-arrayexpress
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