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ProteomicsHAX1-interactome in breast cancer cell line (MCF7)
The MCF7 cell line represents a typical epithelial cell line and corresponds to luminal A breast cancer (estrogen-responsive). Overexpression of HAX1 was demonstrated in MCF7 cell line as well as in breast cancer samples, suggesting a role of HAX1 in breast cancer progression. HAX1 is a 32-kDa prote...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD007888 | Pride
Mcf7 Hax1 Interactome 
ProteomicsDetermination of pancreatic cyst fluids peptidome and proteome
Determination of pancreatic cyst fluids (PCF) peptidome and proteome in 5 distinct patient groups: malignant (CAs), intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs), serous cystic neoplasms (SCNs), and pseudocysts (PCs). The PCF <5kDa fraction, referred as the degra...
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD005248 | Pride
Human Pancreas Cyst fluids Degradome Proteome Lc-ms/ms 
ProteomicsHAX1-interactome in cervical cancer cell line (HeLa)
HAX1 is a 32-kDa protein of unknown structure, involved in the regulation of apoptosis, cell migration and calcium homeostasis. It was also shown to bind mRNA. Scarcity of structural elements and the presence of a disordered region, inferred from HAX1 sequence, suggests that HAX1 is intrinsically di...
ORGANISM(S): Homo sapiens (Human) 
2020-11-11 | PXD007887 | Pride
Hax1 Hela Interactome 
ProteomicsProteomic profiling of CDK8 Inhibition
Acute myeloid leukemia (AML) with leukemic stem cell (LSC) characteristics represents a therapeutic challenge due to inherent resistance to differentiation. CDK8, a kinase component of the Mediator complex, has emerged as a regulator of oncogenic transcription, yet its role in LSC maintenance and po...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD074404 | Pride
Phosphopeptides Chromatin immunoprecipitation Leukemic stem cell Cdk8 kinase Interactome 
TranscriptomicsModeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data
Background. Most colorectal cancers (CRC) arise in a progression through adenoma to carcinoma phenotypes as a consequence of altered genetic information. Clinical progression of CRC may occur in parallel with distinctive signaling alterations. We designed multidirectional analyses integrating microa...
ORGANISM(S): Homo sapiens 
2010-08-01 | E-GEOD-20916 | biostudies-arrayexpress
TranscriptomicsMolecular defense mechanisms of Barrett's metaplasia estimated by an integrative genomics
Barrett's esophagus is characterized by the replacement of squamous epithelium with specialized intestinal metaplastic mucosa. The exact mechanisms of initiation and development of Barrett's metaplasia remain unknown, but a hypothesis of successful adaptation against noxious reflux components has be...
ORGANISM(S): Homo sapiens 
2012-03-08 | E-GEOD-36223 | biostudies-arrayexpress
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