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TranscriptomicsTranscription profiling of mouse Foxp3 ablation in peripheral mature regulatory T cells
Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. R...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6681 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse thymic T cells - Foxp3-dependent programme of regulatory T-cell differentiation (GEO Super Series0
This SuperSeries is composed of the following subset Series:; GSE7280: Gene expression in peripheral cells: effects of Foxp3 and PDE3B; GSE7770: Gene expression in thymic CD4 T cells: effects of Foxp3 Experiment Overall Design: Thymocyte RNA (GSE7770) was processed with Affy and Enzo reagents wherea...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7773 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human thymic T cell subsets T-N, T-25, T-FN and T-R thymocytes
This data set is comprised of all thymic T cell subsets presented in this manuscript. These include T-N, T-25, T-FN and T-R thymocytes. Experiment Overall Design: Detailed methods are presented in the manuscript and in the attached Supplementary Information. All RNA samples were derived from cells i...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7770 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse peripheral T cells subsets: T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells after treatment with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressing retroviral vectors
This data set is comprised of all peripheral (pooled lymph nodes and spleen) T cell subsets presented in this manuscript. These include T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells from mice treated with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressi...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7280 | biostudies-arrayexpress
TranscriptomicsFoxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [Expression]
Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new ...
ORGANISM(S): Mus musculus 
2012-09-28 | E-GEOD-40685 | biostudies-arrayexpress
GenomicsFoxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq]
Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new ...
ORGANISM(S): Mus musculus 
2012-09-28 | E-GEOD-40684 | biostudies-arrayexpress
TranscriptomicsContext- and cell-type specific function of miR155-Socs1 interaction in immune regulation
The microRNA (miRNA) dependent regulation of gene expression confers robustness to cellular phenotypes and controls responses to extracellular stimuli. Although a single miRNA can regulate expression of hundreds of target genes, it is unclear whether any of its distinct biological functions can be d...
ORGANISM(S): Mus musculus 
2015-05-10 | E-GEOD-68511 | biostudies-arrayexpress
TranscriptomicsTreg specific Gata3 knock out array
The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (Treg cells). To gain insights into the molecular mechanisms of Foxp3 mediated gene expression we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric ana...
ORGANISM(S): Mus musculus 
2012-08-28 | E-GEOD-39864 | biostudies-arrayexpress
TranscriptomicsContinuous requirement for the T cell receptor for regulatory T cell function
Foxp3+ regulatory T cells (Treg cells) maintain immunological tolerance and their deficiency results in fatal multi-organ autoimmunity. Although heightened T cell receptor (TCR) signaling is critical for the differentiation of Treg cells, the role of TCR signaling in Treg cell function remains larg...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-61077 | biostudies-arrayexpress
TranscriptomicsHDAC inhibition by TSA and Butyrate In Flt3L-elicited DC
Butyrate induces Treg via HDACi activity Microarray of DC treated with TSA or Butyrate over untreated
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-51263 | biostudies-arrayexpress
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