Sort   by:  
 Page size 
ProteomicsIgf2bp2 deletion reduces energy metabolism, gIgf2bp2 deletion reduces energy metabolism, growth signaling, and aging of hematopoietic stem cells in micerowth signaling, and aging of hematopoietic stem cells in mice
Increasing evidence links metabolic activity and cell growth to decline in hematopoietic stem cell (HSC) function during aging. The Lin28b/Hmga2 pathway controls tissue development and in the hematopoietic system the postnatal downregulation of this pathway causes a decrease in self renewal of adult...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD018535 | Pride
Mitochondrial metabolism Protein synthesis and mtor/pi3k-dependent differentiation of hematopoietic stem cells. Igf2bp2 drives glycolysis 
ProteomicsTnfaip2/Exoc3 controls exit from pluripotency by mediating lipid droplet formation and FA-induced differentiation
The decline in stem cell function leads to impairments in tissue homeostasis but genetic factors that control differentiation and de-differentiation of stem cells in the context of tissue homeostasis remain to be delineated. Here we show that Tnfaip2 (a target gene of TNFa/NFkB signaling) has an ess...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-18 | PXD014628 | Pride
Neoblast Exoc3 Induced pluripotent stem cells Vim Lipid metabolism and fatty acids Tnfaip2 Differentiation Embryonic stem cells Homeostasis 
Sort   by:  
 Page size