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TranscriptomicsExpression and ChIP-seq analyses of embryonic stem cells, extraembryonic endoderm stem cells, and trophoblast stem cells
Bivalent histone domains have been proposed to contribute to pluripotency in embryonic stem cells, suggesting an epigenetic mechanism may regulate stem cell behavior in general. Here we compare histone modifications in two other stem cells derived from the blastocyst. We show that extraembryonic ste...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15519 | biostudies-arrayexpress
TranscriptomicsStem cell lines of the early mouse embryo
Expression profiling of stem cell lines derived from the early embryo representing the trophoblast, primitive endoderm, early epiblast (inner cell mass E3.5) and late post-implantation epiblast (E5.5). Cells were grown without feeders and harvested. Comparisons were made to provide evidence of uniqu...
ORGANISM(S): Mus musculus 
2012-05-21 | E-GEOD-34799 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of naive and primed human pluripotent stem cells treated with SB431542
The aim of this experiment was to investigate the role of TGFβ signalling in human pluripotency, looking at the effect of SB431542 (SB), a potent and selective SMAD inhibitor that blocks TGFβ/Activin receptors ALK5, ALK4, and ALK7, on gene expression. We performed 10X sequencing in naïve and primed ...
ORGANISM(S): Homo sapiens 
2021-08-13 | E-MTAB-10018 | biostudies-arrayexpress
TranscriptomicsIn vitro modelling of the human embryo implantation niche
Single-cell RNA-sequencing (10X) data from a three-dimensional cell-engineered system for human implantation that closely recapitulates the cytoarchitecture and physiology of the receptive human endometrium
ORGANISM(S): Homo sapiens 
2024-07-17 | E-MTAB-13629 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem cells and their differentiated progeny grown in chemically defined conditions
Comparison of H9 human embryonic stem cells, grown in chemically defined and animal-product free conditions, with their differentiated progeny - mesendodermal progenitors arisen as the result of changes made to chemically defined hESC growth conditions. Contributes to a larger work on the use of che...
ORGANISM(S): Homo sapiens 
2009-07-31 | E-MEXP-930 | biostudies-arrayexpress
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