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TranscriptomicsPRAME induced inhibition of retinoic acid receptor signaling-mediated differentiation - a possible target for ATRA response in AML without t(15;17)
Purpose: In acute myeloid leukemia (AML) without retinoic acid receptor (RAR) rearrangement the effect of all-trans retinoic acid (ATRA) is still poorly understood despite an association of NPM1 mutation and ATRA response. Recently, PRAME (preferentially expressed antigen in melanoma) has been shown...
ORGANISM(S): Homo sapiens 
2013-03-10 | E-GEOD-43258 | biostudies-arrayexpress
UnknownApixaban Use in Patients with Kidney Impairment: A Review of Pharmacokinetic, Interventional, and Observational Study Data.
Not available
S-EPMC11344734 | biostudies-literature
ProteomicsMCF7 treated with abemaciclib nuclear Rb IP LC-MSMS
The retinoblastoma protein (Rb) is a tumour suppressor best known for repressing E2F transcription factors and halting cell cycle progression1. In hormone receptor-positive (HR+) breast cancer, CDK4/6 inhibitors activate Rb by preventing its phosphorylation, forming a key component of current endocr...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD066496 | Pride
Rb Lc-msms Cdk4/6i Ip Breast cancer 
TranscriptomicsIntegrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia
Background: MicroRNAs are regulators of gene expression, mainly functioning by decreasing mRNA levels of their multiple targets. Deregulated microRNA expression has been shown for acute myeloid leukemia, a disease also characterized by altered gene expression associated with distinct genomic aberrat...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31644 | biostudies-arrayexpress
UnknownDecadal trends in marine reserves reveal differential rates of change in direct and indirect effects.
Not available
S-EPMC2972978 | biostudies-literature
UnknownSmac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.
Not available
S-EPMC5226527 | biostudies-literature
UnknownThe preferences of people with amyotrophic lateral sclerosis on riluzole treatment in Europe.
Not available
S-EPMC10728064 | biostudies-literature
TranscriptomicsAltered miRNA and gene expression in acute myeloid leukemia with complex karyotype identify networks of prognostic relevance
Recently, the p53-miR-34a network was identified to play an important role in tumorigenesis. As in acute myeloid leukemia with complex karyotype (CK-AML) TP53 alterations are the most common known molecular lesion, we further analyzed the p53-miR-34a axis in CK-AML with known TP53 status. Clinically...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-39730 | biostudies-arrayexpress
UnknownMitochondrial genome sequences reveal evolutionary relationships of the Phytophthora 1c clade species.
Not available
S-EPMC4659649 | biostudies-literature
UnknownWarfarin Time in Therapeutic INR Range and Direct Oral Anticoagulant Adherence for Venous Thromboembolism Across the Spectrum of Weight and Body Mass Index: Findings from Veterans Health Administration.
Not available
S-EPMC9893071 | biostudies-literature
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