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TranscriptomicsTranscription profiling of mouse Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires to investigate the effect of paternal haploinsufficiency for Dnmt3L
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and the early developing embryo. One corollary to this is that disruption of the establishment of epigenetic state in the gametes of a parent, ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7384 | biostudies-arrayexpress
UnknownA Systematic Review of Neighborhood Disparities in Point-of-Sale Tobacco Marketing.
Not available
S-EPMC4529779 | biostudies-literature
UnknownA phase 2 study of AZD4635 in combination with durvalumab or oleclumab in patients with metastatic castration-resistant prostate cancer.
Not available
S-EPMC10908633 | biostudies-literature
UnknownPhase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors.
Not available
S-EPMC9660540 | biostudies-literature
TranscriptomicsTranscriptional dynamics elicited by a short pulse of Notch activation.
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. Here we have analyzed the temporal changes in transcription following a short Notch activation treatment and have related these to the recruitmen...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35557 | biostudies-arrayexpress
TranscriptomicsA host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics.The cyc...
ORGANISM(S): Mus musculus 
2009-07-21 | E-GEOD-16943 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of H3K56ac in Drosophila melanogaster Kc167 cell lines with Lz overexpression
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66223 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of H3K56ac in Drosophila melanogaster BG3 cell lines
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66219 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of Su(H) in Drosophila melanogaster Kc167 cell lines
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66226 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of Su(H) in Drosophila melanogaster BG3 cell lines
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66225 | biostudies-arrayexpress
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