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TranscriptomicsRelief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas.
Analysis of transcriptome kinetics of SW1736 thyroid cancer cell line vs SK-MEL-28 melanoma cell line at various times after addition of 2 µM vemurafenib. The hypothesis tested was that SW1736 cells (vemurafenib-refractory) differentially express genes compared to SK-MEL-28 cells (vemurafenib sensit...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-37441 | biostudies-arrayexpress
UnknownAdvanced platelet-rich fibrin and freeze-dried bone allograft for ridge preservation: A randomized controlled clinical trial.
Not available
S-EPMC6483085 | biostudies-literature
TranscriptomicsIncreased mutability of staphylococci in biofilms as a consequence of oxidative stress
In this work we have demonstrated increased mutability of Staphylococcus aureus and S. epidermidis in biofilms and have explored the mechanisms underlying the enhanced mutability. A novel static biofilm model, utilising cellulose filter disks, was developed to support the formation of mature biofilm...
ORGANISM(S): Staphylococcus aureus 
2012-03-01 | E-GEOD-35837 | biostudies-arrayexpress
UnknownAn Automated Purification Workflow Coupled with Material-Sparing High-Throughput <sup>1</sup>H NMR for Parallel Medicinal Chemistry.
Not available
S-EPMC11403749 | biostudies-literature
UnknownProbe selection for high-density oligonucleotide arrays.
Not available
S-EPMC208741 | biostudies-literature
ProteomicsCharacterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...
ORGANISM(S): Homo sapiens (Human) 
2017-09-07 | PXD007629 | Pride
Human embryonic kidney (hek) suspension cells Sumo2 
UnknownDeterminants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy.
Not available
S-EPMC6392208 | biostudies-literature
UnknownAmerican Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer: Defining advanced thyroid cancer and its targeted treatment.
Not available
S-EPMC9332138 | biostudies-literature
ProteomicsUntargeted proteomics enables ultra-rapid variant prioritization in mitochondrial and other rare diseases
Only half of individuals with suspected rare diseases receive a definitive genetic diagnosis following genomic testing. A genetic diagnosis allows access to appropriate patient care and reduces the number of potentially unnecessary interventions and related healthcare costs. Here, we demonstrate tha...
ORGANISM(S): Homo sapiens (Human) 
2024-09-03 | PXD055473 | Pride
Human Fibroblasts Pbmcs Hek293t Orbitrap 
ProteomicsNUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detected homozygosity for a single deleterious missense variant in the gene NudC domain containing 3 (NUD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD035840 | Pride
Pulldown Nudcd3 Proteomics Omenn syndrome 
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