S. aureus targeting

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Unknown (815)
Genomics (49)
Transcriptomics (37)
Proteomics (35)
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Models (3)
Other (2)

Organisms

Staphylococcus aureus (40)
Homo sapiens (14)
Mus musculus (7)
Escherichia coli (5)
Staphylococcus aureus subsp. aureus Mu50 (2)
Danio rerio (2)
Staphylococcus aureus subsp. aureus USA300_FPR3757 (2)
Thermus thermophilus HB8 (1)
Borreliella burgdorferi B31 (1)
Chlamydia caviae GPIC (1)
Chlamydia muridarum (1)
Chlamydia pneumoniae AR39 (1)
Chlamydia trachomatis D/UW-3/CX (1)
Coxiella burnetii (1)
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Granulibacter bethesdensis (1)
Rickettsia rickettsii (1)
Staphylococcus aureus subsp. aureus MW2 (1)
Staphylococcus aureus subsp. aureus N315 (1)
Staphylococcus epidermidis (1)
Staphylococcus epidermidis ATCC 12228 (1)
Staphylococcus epidermidis RP62A (1)
Staphylococcus haemolyticus (1)
Staphylococcus haemolyticus JCSC1435 (1)
Staphylococcus aureus subsp. aureus NCTC 8325 (1)
Bacteria (1)
Staphylococcus aureus subsp. aureus USA300_TCH1516 (1)

Organisms

Staphylococcus aureus (16)
Homo sapiens (7)
Mus musculus (4)
Staphylococcus aureus subsp. aureus USA300_FPR3757 (1)
Dubowvirus (1)
Bacillus subtilis group (1)
Staphylococcus haemolyticus (1)
Escherichia coli (1)

Repository

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geo (24)
pride (22)
biostudies-arrayexpress (16)
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Tissue

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Biofilm (1)
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Disease

Opportunistic bacterial infectious disease (1)

Technology Type

Mass Spectrometry (22)
Bottom-up proteomics (11)
Shotgun proteomics (8)
Mass spectrometry (5)
Data-dependent acquisition (3)
Mass spectrometry assay (1)
All-ion fragmentation (1)
DiaPASEF (1)
Gel-based experiment (1)
SWATH MS (1)

Instrument Platform

Synapt XS (2)
Liquid Chromatography MS - negative - hilic (2)
Liquid Chromatography MS - negative - reverse phase (2)
Liquid Chromatography MS - positive - hilic (2)
Illumina HiSeq 2000 (1)
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Liquid Chromatography MS - alternating (1)
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Liquid Chromatography MS - positive - reverse-phase (1)

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2021 (2)
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2016 (1)
2015 (1)
2012 (1)
2008 (1)
2018 (1)
2019 (1)

CHEBI ID

CHEBI:10049 (2)
CHEBI:10082 (2)
CHEBI:10444 (2)
CHEBI:15641 (2)
CHEBI:15743 (2)
CHEBI:15746 (2)
CHEBI:15799 (2)
CHEBI:15891 (2)
CHEBI:15947 (2)
CHEBI:16019 (2)
CHEBI:16335 (2)
CHEBI:16356 (2)
CHEBI:16467 (2)
CHEBI:16556 (2)
CHEBI:16562 (2)
CHEBI:16566 (2)
CHEBI:16587 (2)
CHEBI:16691 (2)
CHEBI:16731 (2)
CHEBI:16742 (2)
CHEBI:16805 (2)
CHEBI:168124 (2)
CHEBI:16871 (2)
CHEBI:16874 (2)
CHEBI:17169 (2)
CHEBI:17295 (2)
CHEBI:17302 (2)
CHEBI:17327 (2)
CHEBI:17361 (2)
CHEBI:17368 (2)

Metabolite Name

Agmatine (3)
Benzaldehyde (3)
Dichlorvos (3)
Doxorubicin (3)
Haloperidol (3)
Imidazoleacetic acid ribotide (3)
L-Tyrosine (3)
LysoPE(18:0/0:0) (3)
Monocrotaline (3)
N-Acetyl-b-glucosaminylamine (3)
Nefazodone (3)
Nicotinic acid (3)
Orotic acid (3)
Paraoxon (3)
Selenocysteine (3)
Sphinganine (3)
Tacrine (3)
Taurine (3)
Thiamine monophosphate (3)
Uric acid (3)
Vecuronium (3)
Xanthosine 5-triphosphate (3)
(2R,3S)-Piscidic acid (2)
(S)-3-Hydroxyhexadecanoyl-CoA (2)
16-Hydroxy hexadecanoic acid (2)
2,2-dichloro-1,1-ethanediol (2)
2-Methoxy-estradiol-17b 3-glucuronide (2)
2-Phenylacetamide (2)
2-Phenylethanol (2)
2-Propyn-1-al (2)

IsPrivate

False (3)

Submitter Keywords

Not Peer Reviewed (1)

First Public Date

2025 (12)
2026 (8)
2024 (8)
2014 (6)
2023 (5)
2017 (3)
2016 (2)
2021 (1)
2019 (1)
2018 (1)
2015 (1)

Classification

bacteria (18)
viruses (1)

Modelling Approach

Constraint-based model (3)

Study type

Transcription profiling by array (6)
Comparative genomic hybridization by array (3)
Transcription profiling by tiling array (2)
RNA-seq of coding RNA (2)
Unknown experiment type (1)
ChIP-chip by tiling array (1)
Other (1)

Release Date

2025 (146)
2023 (98)
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2022 (82)
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2020 (53)
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2017 (30)
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2014 (24)
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2011 (9)
2009 (5)
2008 (5)
2006 (5)
2005 (3)
2004 (3)
2001 (2)
2007 (1)
2002 (1)
2000 (1)
1999 (1)

Lab affiliation

Department of Molecular Biosciences, University of South Florida, Tampa, FL, USA Center for Antimicrobial Resistance, University of South Florida, Tampa, FL, USA (4)
Architecture et Réactivité de l'ARN, CNRS 9002, Université de Strasbourg, Strasbourg, France (1)
Center for Functional Protein Assemblies, Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich, Ernst-Otto-Fischer-Straße 8, D-85748 Garching, Germany (1)
Chair of Microbiology Biocenter, University of Würzburg D-97074 Würzburg, GERMANZ (1)
Chemical and Biological Engineering Department, The Hong Kong University of Science and Technology (HKUST) (1)
Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University (1)
Department of Chemistry, Indian Institute of Science Education and Research Bhopal (IISERB, India (1)
Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching, Germany (1)
Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim, Norway (1)
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom (1)
Head of Proteomics (1)
Instructor in Medicine, Division of Infectious Diseases, Vanderbilt University (1)
MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China (1)
MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, Jinan University, Guangzhou 510632, China (1)
Medimmune LLC (1)
Research group for Host-Microbe Interaction Department of Medical Biology Faculty of Health Sciences UiT- The Arctic University of Norway 9037 Tromsø NORWAY (1)
Technical University Munich, Department of Chemistry, Lichtenbergstrasse 4, 85748 Garching bei Muenchen, Germany (1)
Technical University of Munich (1)
Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France. (1)

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Systematic identification of bacterial factors driving Staphylococcus aureus intracellular lifestyle in non-professional phagocytes

Staphylococcus aureus is a major human pathogen responsible for severe infections. While traditionally described as extracellular, increasing evidence establishes S. aureus as a facultative intracellular pathogen. Intracellularity contributes to immune evasion, dissemination, and antibiotic failu...

2025-10-26 | MTBLS13220 | MetaboLights

Discovery of isokurarinone as an ATCase-Engaging Lead with potent activity against methicillin-resistant Staphylococcus aureus

The global proliferation of methicillin-resistant Staphylococcus aureus (MRSA) persists as a significant contributor to challenging infections, highlighting the urgent necessity for therapies that utilize novel mechanisms. Aspartate transcarbamoylase (ATCase), which catalyzes the initial committe...

2026-01-14 | MTBLS13673 | MetaboLights

StaphVar-DNA microarray analysis of accessory genome of community-acquired methicillin resistant Staphylococcus aureus

Approximatively 75% of the genome of S. aureus (“core” genome) are highly conserved between strains, whereas the remaining 25% (“accessory” genome) are composed of variable regions that are mostly composed of mobile genetic elements (MGE), containing virulence and resistance genes. We have developed...

ORGANISM(S): Staphylococcus aureus

2009-02-14 | E-GEOD-13702 | biostudies-arrayexpress

A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation.

Analysis of the intergenic regions of Staphylococcus aureus by bioinformatics predicted multiple regulatory regions. From this analysis, we also characterized 11 novel noncoding RNAs (RsaA-K) that are expressed in several S. aureus strains under different experimental conditions. Many of them accumu...

ORGANISM(S): Staphylococcus aureus

2010-05-18 | E-GEOD-17135 | biostudies-arrayexpress

Response of methicillin-resistant Staphylococcus aureus USA300 to a subinhibitory concentration of thioridazine - alone and in combination with dicloxacillin

Subinhibitory concentrations of the neuroleptic drug thioridazine (TDZ) are well-known to enhance the killing of methicillin-resistant S. aureus (MRSA) by Î²-lactam antibiotics, however, the mechanism underlying the synergy between TDZ and Î²-lactams is not fully understood. In the present study we ...

ORGANISM(S): Staphylococcus aureus subsp. aureus USA300_FPR3757

2013-05-20 | E-GEOD-43759 | biostudies-arrayexpress

Effect of Hamamelitannin, vancomycin and combination treatment of Hamamelitannin and vancomycin on gene expression in S. aureus Mu50 biofilms

Novel anti-infective agents targeting Staphylococcus aureus and capable of increasing S. aureus susceptibility towards antibiotics are needed. One alternative approach is targeting the bacterial quorum sensing (QS) system. QS is a process by which bacteria produce and detect signal molecules and the...

ORGANISM(S): Staphylococcus aureus subsp. aureus Mu50

2017-08-25 | E-MTAB-3816 | biostudies-arrayexpress

Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence

Staphylococcus aureus is a major human pathogen and resistant to numerous clinically used antibiotics. The first antibiotic developed for S. aureus infections was the nonribosomal petide secondary metabolite penicillin. We discovered cryptic nonribosomal peptide secondary metabolites, the aureusimi...

ORGANISM(S): Staphylococcus aureus

2010-07-30 | E-GEOD-21373 | biostudies-arrayexpress

Electronically tuned N-terminal glycine selective bioconjugation enables in vitro and in vivo species-specific Staphylococcus aureus targeting

Precisely targeting a biomolecule within living systems could create unique opportunities at the biology-medicine interface. Such methods have been non-trivial due to the complex selectivity attributes. Here, we introduce an electronically tunable chemical technology that targets N-terminal glycine,...

ORGANISM(S): Bacteria Staphylococcus aureus

2026-10-05 | PXD082695 | Pride

S. aureus targeting

Repurposing cinacalcet suppresses multi-drug resistant Staphylococcus aureus by disruption of cell membrane and inhibits biofilm by targeting IcaR

Multi-drug resistant Staphylococcus aureus (S. aureus) infections continously threaten public health. The rapid escalation in morbidity and mortality rates associated with methicillin-resistant S. aureus (MRSA) infections necessitates the urgent development of novel antimicrobial agents. Our study r...

ORGANISM(S): Staphylococcus aureus

2024-02-07 | PXD041266 | Pride

Mutidrug-resistance s. aureus cinacalcet icar membrane

NIH/NIAID On the resistance of Staphylococcus aureus to neutrophil microbicides

Staphylococcus aureus strain MW2 was exposed to the following neutrophil microbicides, hydrogen peroxide (H2O2), hypochlorous acid (HOCl) and azurophilic granule proteins. At the indicated time points, bacterial cultures were centrifuged and bacteria were lysed with RLT buffer (Qiagen) using a Fast...

ORGANISM(S): Staphylococcus aureus

2010-05-26 | E-GEOD-6716 | biostudies-arrayexpress

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